SYNTHESIS OF 6-R-3-(2-AMINOPHENYL)-2H-1,2,4-TRIAZIN-5-ONES: RESOURCES AND LIMITATIONS

被引：3
|
作者：
Voskoboynik, Alexey [1 ]
Berest, Galina [1 ]
Skorina, Dmitriy [1 ]
Karpenko, Alexander [1 ]
Kovalenko, Sergey [1 ]
机构：
[1] Zaporizhzhya State Med Univ, Dept Pharmaceut Chem, 26 Mayakovsky Ave, UA-69035 Zaporizhzhya, Ukraine
来源：
CHEMISTRY & CHEMICAL TECHNOLOGY | 2011年 / 5卷 / 02期
关键词：
6-R-3-(2-aminophenyl)-2H-[1,2,4]triazin-5-ones; hydrazinolysis; nucleophylic cleavage;
D O I：
10.23939/chcht05.02.129
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The novel methods of 6-R-3-(2-aminophenyl)2H-1,2,4-triazin-5-ones synthesis by 2-R-[(3H-quinazoline4-yliden) hydrazono]-alpha-carboxylic acid esters hydrazinolysis and nucleophylic cleavage of 3-R-2H[ 1,2,4] triazino[2,3-c] quinazoline-2-ones are worked out. It is shown that 2-R-[(3H-quinazoline-4-yliden) hydrazono]a -carboxylic acid esters under hydrazinolysis form (3H-quinazoline-4-yliden) hydrazine or 6-R-3-(2-aminophenyl)2H-1,2,4-triazin-5-ones. The reaction direction depends on geometric isomerism of corresponding esters.
引用
收藏
页码：129 / 132
页数：4
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