SYNTHESIS OF 6-R-3-(2-AMINOPHENYL)-2H-1,2,4-TRIAZIN-5-ONES: RESOURCES AND LIMITATIONS

被引：3

作者：

Voskoboynik, Alexey ^{[1
]}

Berest, Galina ^{[1
]}

Skorina, Dmitriy ^{[1
]}

Karpenko, Alexander ^{[1
]}

Kovalenko, Sergey ^{[1
]}

机构：

[1] Zaporizhzhya State Med Univ, Dept Pharmaceut Chem, 26 Mayakovsky Ave, UA-69035 Zaporizhzhya, Ukraine

来源：

CHEMISTRY & CHEMICAL TECHNOLOGY | 2011年 / 5卷 / 02期

关键词：

6-R-3-(2-aminophenyl)-2H-[1,2,4]triazin-5-ones; hydrazinolysis; nucleophylic cleavage;

D O I：

10.23939/chcht05.02.129

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The novel methods of 6-R-3-(2-aminophenyl)2H-1,2,4-triazin-5-ones synthesis by 2-R-[(3H-quinazoline4-yliden) hydrazono]-alpha-carboxylic acid esters hydrazinolysis and nucleophylic cleavage of 3-R-2H[ 1,2,4] triazino[2,3-c] quinazoline-2-ones are worked out. It is shown that 2-R-[(3H-quinazoline-4-yliden) hydrazono]a -carboxylic acid esters under hydrazinolysis form (3H-quinazoline-4-yliden) hydrazine or 6-R-3-(2-aminophenyl)2H-1,2,4-triazin-5-ones. The reaction direction depends on geometric isomerism of corresponding esters.

引用

页码：129 / 132

页数：4

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