DESIGN, SYNTHESIS AND VIRTUAL SCREENING OF CERTAIN 2-PYRAZOLIN-5-ONE AND PYRAZOLIDINE-3, 5-DIONE DERIVATIVES AS POTENTIAL PPAR gamma AGONISTS

被引：4

作者：

Ismaila, Mohamed A. H. ^{[1
]}

El Ella, Dalal A. Abou ^{[1
]}

Abouzid, Khaled A. M. ^{[1
]}

Jaballah, Maiy ^{[1
]}

机构：

[1] Ain Shams Univ, Fac Pharm, Dept Pharmaceut Chem, El Khalifa ElMaamoon St, Cairo 11566, Egypt

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2012年 / 3卷 / 10期

关键词：

PPAR gamma; Pyrazolin-5-one; Pyrazolidine-3; 5-dione; Design;

D O I：

10.13040/IJPSR.0975-8232.3(10).3746-57

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In the quest for novel PPAR gamma agonists as putative drugs for the treatment of type 2 diabetes, a new series of 2-pyrazolin-5-one and pyrazolidine-3, 5-dione derivatives, were designed and synthesized, as analogues to the antidiabetic thiazolidinedione agents (TZDs). Extensive molecular modeling studies for the designed molecules were performed; including their compare-fit studies on the generated and validated PPAR gamma agonist's hypothesis and their molecular docking on the binding sites of the 3D structure of the PPAR gamma receptors.

引用

页码：3746 / 3757

页数：12

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[11] Synthesis, IR and 13C-NMR spectral studies of some 2-pyrazolin-5-one derivatives
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KHAN, IB
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