Synthesis and Microbial Activity of Novel 3-Methyl-2-pyrazolin-5-one Derivatives

被引：3
|
作者：
Mostafa, Mohamed S. [1 ]
Abd El-Salam, Nasser M. [2 ]
Alothman, Othman Y. [3 ]
机构：
[1] Jazan Univ, Fac Sci, Dept Chem, Jazan, Saudi Arabia
[2] King Saud Univ, Riyadh Community Coll, Riyadh 11437, Saudi Arabia
[3] King Saud Univ, Coll Engn, Dept Chem Engn, Riyadh 11421, Saudi Arabia
来源：
JOURNAL OF CHEMISTRY | 2013年 / 2013卷
关键词：
D O I：
10.1155/2013/183130
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
2-Oxo-2H-chromene-3-carbohydrazide derivatives 2a, b react with 2-{[4-(substituted thiazol-2-yl)iminoethyl)-phenyl]hydrazono}-3-oxo-butyric acid ethyl esters 4a-c to give 3-methyl-1-[(2-oxo-2H-chromen-3-yl) carbonyl]-4-{[4-(substituted thiazol-2-yl)iminoethyl)-phenyl]hydrazono}]-2-pyrazolin-5-one derivatives 5a-f. A considerable increase in the reaction rate had been observed with better yield using microwave irradiation for the synthesis of compounds 2a, b, 3a-c, and 5a-f. The synthesized products were tested against B. subtilis, S. aureus, and E. coli as well as C. albicans compared with tetracycline and nystatin as reference drugs.
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页数：7
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