MOLECULAR CHARACTERIZATION OF A DROSOPHILA-MELANOGASTER VARIANT STRAIN DEFECTIVE IN THE SGS-4 GENE DOSAGE COMPENSATION

被引：1

作者：

FURIA, M ^{[1
]}

DIGILIO, FA ^{[1
]}

ARTIACO, D ^{[1
]}

FAVIA, G ^{[1
]}

POLITO, LC ^{[1
]}

机构：

[1] CNR,IST BIOCHIM PROT & ENZIMOL,NAPLES,ITALY

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1992年 / 1130卷 / 03期

关键词：

GLUE PROTEIN; DOSAGE COMPENSATION; GENE; NUCLEOTIDE SEQUENCE; (DROSOPHILA);

D O I：

10.1016/0167-4781(92)90444-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The X-linked Sgs-4 gene of Drosophila melanogaster encodes a salivary glue protein. Here we report the molecular characterization of a non-dosage compensated variant strain, named Karsnas, in which males accumulate only about half of the Sgs-4 polypeptide amount as do females. The results obtained show that significant nucleotide sequence alterations are accumulated within the Sgs-4 coding and 3' untranslated region of the variant strain, thus suggesting a possible role of these sequences in the Sgs-4 dosage compensation.

引用

页码：314 / 316

页数：3

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