MOLECULAR CHARACTERIZATION OF A DROSOPHILA-MELANOGASTER VARIANT STRAIN DEFECTIVE IN THE SGS-4 GENE DOSAGE COMPENSATION

被引：1
|
作者：
FURIA, M [1 ]
DIGILIO, FA [1 ]
ARTIACO, D [1 ]
FAVIA, G [1 ]
POLITO, LC [1 ]
机构：
[1] CNR,IST BIOCHIM PROT & ENZIMOL,NAPLES,ITALY
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1992年 / 1130卷 / 03期
关键词：
GLUE PROTEIN; DOSAGE COMPENSATION; GENE; NUCLEOTIDE SEQUENCE; (DROSOPHILA);
D O I：
10.1016/0167-4781(92)90444-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The X-linked Sgs-4 gene of Drosophila melanogaster encodes a salivary glue protein. Here we report the molecular characterization of a non-dosage compensated variant strain, named Karsnas, in which males accumulate only about half of the Sgs-4 polypeptide amount as do females. The results obtained show that significant nucleotide sequence alterations are accumulated within the Sgs-4 coding and 3' untranslated region of the variant strain, thus suggesting a possible role of these sequences in the Sgs-4 dosage compensation.
引用
收藏
页码：314 / 316
页数：3
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