MOLECULAR CHARACTERIZATION OF A DROSOPHILA-MELANOGASTER VARIANT STRAIN DEFECTIVE IN THE SGS-4 GENE DOSAGE COMPENSATION

被引：1
|
作者：
FURIA, M [1 ]
DIGILIO, FA [1 ]
ARTIACO, D [1 ]
FAVIA, G [1 ]
POLITO, LC [1 ]
机构：
[1] CNR,IST BIOCHIM PROT & ENZIMOL,NAPLES,ITALY
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1992年 / 1130卷 / 03期
关键词：
GLUE PROTEIN; DOSAGE COMPENSATION; GENE; NUCLEOTIDE SEQUENCE; (DROSOPHILA);
D O I：
10.1016/0167-4781(92)90444-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The X-linked Sgs-4 gene of Drosophila melanogaster encodes a salivary glue protein. Here we report the molecular characterization of a non-dosage compensated variant strain, named Karsnas, in which males accumulate only about half of the Sgs-4 polypeptide amount as do females. The results obtained show that significant nucleotide sequence alterations are accumulated within the Sgs-4 coding and 3' untranslated region of the variant strain, thus suggesting a possible role of these sequences in the Sgs-4 dosage compensation.
引用
收藏
页码：314 / 316
页数：3
相关论文
共 50 条
  • [1] DOSAGE COMPENSATION AT THE SGS4 LOCUS OF DROSOPHILA-MELANOGASTER
    KAISER, K
    FURIA, M
    GLOVER, DM
    JOURNAL OF MOLECULAR BIOLOGY, 1986, 187 (04) : 529 - 536
  • [2] VARIEGATED EXPRESSION OF THE SGS-4 LOCUS IN DROSOPHILA-MELANOGASTER
    KORNHER, JS
    KAUFFMAN, SA
    CHROMOSOMA, 1986, 94 (03) : 205 - 216
  • [3] REGULATION OF THE LARVAL SECRETION PROTEIN GENE SGS-4 ACTIVITY IN DROSOPHILA-MELANOGASTER
    KRUMM, A
    HOFMANN, A
    ROTH, G
    KORGE, G
    BIOLOGICAL CHEMISTRY HOPPE-SEYLER, 1985, 366 (02): : 120 - 121
  • [4] PROXIMITY-DEPENDENT ENHANCEMENT OF SGS-4 GENE-EXPRESSION IN DROSOPHILA-MELANOGASTER
    KORNHER, JS
    BRUTLAG, D
    CELL, 1986, 44 (06) : 879 - 883
  • [5] GENE DOSAGE COMPENSATION IN DROSOPHILA-MELANOGASTER
    LUCCHESI, JC
    MANNING, JE
    ADVANCES IN GENETICS INCORPORATING MOLECULAR GENETIC MEDICINE, 1987, 24 : 371 - 429
  • [6] A CYTOLOGICAL APPROACH TO THE ORDERING OF EVENTS IN GENE ACTIVATION USING THE SGS-4 LOCUS OF DROSOPHILA-MELANOGASTER
    STEINER, EK
    EISSENBERG, JC
    ELGIN, SCR
    JOURNAL OF CELL BIOLOGY, 1984, 99 (01): : 233 - 238
  • [7] GENE DOSAGE COMPENSATION IN TRISOMIES OF DROSOPHILA-MELANOGASTER
    DEVLIN, RH
    GRIGLIATTI, TA
    HOLM, DG
    DEVELOPMENTAL GENETICS, 1985, 6 (01): : 39 - 58
  • [8] DOSAGE COMPENSATION OF THE PERIOD GENE IN DROSOPHILA-MELANOGASTER
    COOPER, MK
    HAMBLENCOYLE, MJ
    LIU, X
    RUTILA, JE
    HALL, JC
    GENETICS, 1994, 138 (03) : 721 - 732
  • [9] REGULATORY SEQUENCES OF THE SGS-4 GENE OF DROSOPHILA-MELANOGASTER ANALYZED BY P ELEMENT-MEDIATED TRANSFORMATION
    HOFMANN, A
    KEINHORST, A
    KRUMM, A
    KORGE, G
    CHROMOSOMA, 1987, 96 (01) : 8 - 17
  • [10] PROMOTER IS AN IMPORTANT DETERMINANT OF DEVELOPMENTALLY REGULATED PUFFING AT THE SGS-4 LOCUS OF DROSOPHILA-MELANOGASTER
    KORGE, G
    HEIDE, I
    SEHNERT, M
    HOFMANN, A
    DEVELOPMENTAL BIOLOGY, 1990, 138 (02) : 324 - 337
12345