APICAL EXPRESSION OF HERPES-SIMPLEX VIRUS TYPE-2 GLYCOPROTEINS IN HUMAN NEUROBLASTOMA-CELLS

被引：2
|
作者：
NIELSEN, LN [1 ]
WHITLEY, RJ [1 ]
CHATTERJEE, S [1 ]
机构：
[1] UNIV ALABAMA, DEPT PEDIAT, 988 BASIC HLTH SCI BLDG, BIRMINGHAM, AL 35294 USA
来源：
VIROLOGY | 1991年 / 185卷 / 02期
关键词：
D O I：
10.1016/0042-6822(91)90571-R
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The expression of herpes simplex virus type 2 (HSV-2) glycoproteins on the surface of human neuroblastoma cells has been investigated using Millipore Millicell culture plate inserts. Utilizing a modified radioimmunoassay, we learned that glycoproteins B, C, D, E, and I were expressed predominantly on the apical membrane domain of the infected neuroblastoma cells. The unidirectional transport of HSV-2 glycoproteins was substantiated by the analysis of extracellular glycoproteins released from neuroblastoma cells. The results suggest that the evaluated HSV-2 glycoproteins were transported primarily to the apical plasma membrane domain of human neuroblastoma cells. © 1991.
引用
收藏
页码：908 / 910
页数：3
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