ASSESSMENT OF ANXIOLYTIC EFFECT OF HANGE-KOBOKU-TO WITH ELEVATED PLUS-MAZE TEST IN MICE

被引：0
|
作者：
KURIBARA, H
MARUYAMA, Y
机构：
[1] GUNMA UNIV,SCH MED,BEHAV RES INST,DEPT NEUROBIOL & BEHAV,MAEBASHI,GUMMA 371,JAPAN
[2] GUNMA UNIV,SCH MED,DEPT NEUROPSYCHOPHARMACOL,GUNMA,JAPAN
来源：
JAPANESE JOURNAL OF NEUROPSYCHOPHARMACOLOGY | 1995年 / 17卷 / 05期
关键词：
HANGE-KOBOKU-TO; DIAZEPAM; ELEVATED PLUS-MAZE; ANXIOLYTIC EFFECT; MICE;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The anxiolytic effect of Hange-Koboku-To in mice was assessed with the elevated plus-maze test. The mice given Hange-Koboku-To (0 : distilled water, 0.5, 1 and 2 g/kg p.o., daily for 7 days) showed a slight but significant increase in staying time in open arms'' when the behavioral test was carried out on the day after the final administration. Diazepam (0.5 and 1 mg/kg s.c.), a benzodiazepine anxiolytic, dose-dependently increased the staying time in ''open arms'', and the effect was enhanced by Hange-Koboku-To. However, the ambulatory activity of mice was not affected by any treatments with these drugs. The present results suggest that Hange-Koboku-To not only has a weak anxiolytic effect, but also enhances the anxiolytic effect of diazepam.
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页码：353 / 358
页数：6
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