ANXIOLYTIC EFFECT OF CCK-ANTAGONISTS ON PLUS-MAZE BEHAVIOR IN MICE

被引：73
|
作者：
RATAUD, J [1 ]
DARCHE, F [1 ]
PIOT, O [1 ]
STUTZMANN, JM [1 ]
BOHME, GA [1 ]
BLANCHARD, JC [1 ]
机构：
[1] RHONE POULENC SANTE,CTR RECH VITRY ALFORTVILLE,DEPT BIOL,13 QUAI JULES GUESDE,F-94403 VITRY,FRANCE
来源：
BRAIN RESEARCH | 1991年 / 548卷 / 1-2期
关键词：
ANXIETY; PLUS-MAZE TEST IN MICE; BEHAVIORAL STUDY; CHOLECYSTOKININ ANTAGONIST; CCK-A RECEPTOR; CCK-B RECEPTOR;
D O I：
10.1016/0006-8993(91)91139-R
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effects of systemic treatment with the CCK-B receptor antagonist L-365,260, its 3S-(-) enantiomer and the CCK-A receptor antagonist devazepide were assessed in the plus-maze procedure in mice. L-365,260 (1-1000-mu-g.kg-1 i.p.) produced a dose-dependent increase in the percentage of entries into, and the percentage of time spent in the open arms. Total arm entry was not consistently modified. Neither the 3S-(-) enantiomer of L-365,260 nor devazepide (both administered at 100-10.000-mu-g.kg-1) enhanced the exploratory behavior of mice. These results suggest that CCK-B, rather than CCK-A antagonists may possess 'anxiolytic' properties in mice.
引用
收藏
页码：315 / 317
页数：3
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