RECBC PROMOTED REPAIR OF BLEOMYCIN DAMAGE IN ESCHERICHIA-COLI

被引：3
|
作者：
KNEZEVICVUKCEVIC, J [1 ]
SIMIC, D [1 ]
机构：
[1] UNIV BELGRADE,FAC SCI,INST BOT,MICROBIOL LAB,43 TAKOVSKA,YU-11000 BELGRADE,YUGOSLAVIA
来源：
BIOCHIMIE | 1991年 / 73卷 / 04期
关键词：
RECOMBINATION DEFICIENCY; BLEOMYCIN; REPAIR OF DNA STRAND BREAKS;
D O I：
10.1016/0300-9084(91)90118-K
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The repair response of Escherichia coli K-12 to bleomycin was examined in Rec-mutants showing differential sensitivity to this agent. Sedimentation analysis of the cellular DNA showed incision after bleomycin treatment. The subsequent reformation of the DNA, found in the wild-type and the recD mutant, was abolished in the recB and delayed in the recF and recBC sbcB mutants. The bleomycin-induced SOS response was reduced in strains containing recB or recBC sbsB mutations. It is suggested that the RecBCD pathway has the main role in the efficient repair of bleomycin-induced DNA damage.
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页码：497 / 500
页数：4
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