RECBC PROMOTED REPAIR OF BLEOMYCIN DAMAGE IN ESCHERICHIA-COLI

被引：3

作者：

KNEZEVICVUKCEVIC, J ^{[1
]}

SIMIC, D ^{[1
]}

机构：

[1] UNIV BELGRADE,FAC SCI,INST BOT,MICROBIOL LAB,43 TAKOVSKA,YU-11000 BELGRADE,YUGOSLAVIA

来源：

BIOCHIMIE | 1991年 / 73卷 / 04期

关键词：

RECOMBINATION DEFICIENCY; BLEOMYCIN; REPAIR OF DNA STRAND BREAKS;

D O I：

10.1016/0300-9084(91)90118-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The repair response of Escherichia coli K-12 to bleomycin was examined in Rec-mutants showing differential sensitivity to this agent. Sedimentation analysis of the cellular DNA showed incision after bleomycin treatment. The subsequent reformation of the DNA, found in the wild-type and the recD mutant, was abolished in the recB and delayed in the recF and recBC sbcB mutants. The bleomycin-induced SOS response was reduced in strains containing recB or recBC sbsB mutations. It is suggested that the RecBCD pathway has the main role in the efficient repair of bleomycin-induced DNA damage.

引用

页码：497 / 500

页数：4

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