ANNELATED PIPERAZINYL-7,8-DIHYDRO-6H-THIOPYRANO[3,2-D]PYRIMIDINES

被引：5
|
作者：
WU, MT
MACCOSS, M
IKELER, TJ
HIRSHFIELD, J
ARISON, BH
TOLMAN, RL
机构：
[1] Merck Sharp and Dohme Research Laboratories, Rahway, New Jersey
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 1990年 / 27卷 / 06期
关键词：
D O I：
10.1002/jhet.5570270607
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Tricyclic analogs of piperazinylthiopyrano[3,2‐d]pyrimidine hypoglycemic agents were prepared. The angular tricyclic systems, 8,9‐dihydro‐7H‐thiopyrano[2,3‐e][1,2,4]triazolo[4,3‐a]pyrimidine and 8,9‐dihydro‐7H‐tetrazolo[1,5‐a]thiopyrano[2,3‐e]pyrimidine derivatives were synthesized from 2,4‐dichloro‐7,8‐dihydro‐6H‐thiopyrano[3,2‐d]pyrimidine in three step sequences. Derivatives of the linear tricyclic system, 5,6‐dihydro‐7H‐thiopyrano[3,2‐d][1,2,4]triazolo[2,3‐a]pyrimidine, were prepared by condensation of 3‐amino‐1,2,4‐triazole with ethyl 3‐oxo‐tetrahydropyran‐2‐carboxylate. The tricyclic heteroaryl‐piperazines lacked significant hypoglycemic activity. Copyright © 1990 Journal of Heterocyclic Chemistry
引用
收藏
页码：1559 / 1563
页数：5
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