INCREASED PLATELET 3H-IMIPRAMINE BINDING AND MONOAMINE OXIDASE-B ACTIVITY IN ALZHEIMERS-DISEASE

被引：13

作者：

BONUCCELLI, U ^{[1
]}

PICCINI, P ^{[1
]}

MARAZZITI, D ^{[1
]}

CASSANO, GB ^{[1
]}

MURATORIO, A ^{[1
]}

机构：

[1] UNIV PISA,INST PSYCHIAT,I-56100 PISA,ITALY

来源：

JOURNAL OF NEURAL TRANSMISSION-PARKINSONS DISEASE AND DEMENTIA SECTION | 1990年 / 2卷 / 02期

关键词：

3 H-imipramine binding; Alzheimer's disease; monoamine oxidase B; Platelet;

D O I：

10.1007/BF02260901

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Several biochemical abnormalities in peripheral tissues have been reported in Alzheimer's disease (AD). With this in mind we studied platelet monoamine oxidase B (MAO B) activity and 3H-imipramine (IMI) binding in both AD patients and healthy subjects and found a significantly higher level of platelet MAO B activity and 3 H-IMI Bmax values in the AD patients. In view of the part that MAO B plays in metabolizing serotonin (5 HT) and of the relationship which exists between 3 H-IMI binding and 5 HT uptake, our results would suggest that with AD there occurs a complex dysfunction in the 5 HT system, at least at a peripheral level. © 1990 Springer-Verlag.

引用

页码：139 / 147

页数：9

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