PLATELET [H-3] PAROXETINE BINDING TO 5-HT UPTAKE SITES IN ALZHEIMERS-DISEASE

被引：8
|
作者：
ANDERSSON, A
ADOLFSSON, R
ERIKSSON, K
MARCUSSON, J
机构：
[1] UNIV LINKOPING,DEPT GERIATR MED,S-58246 LINKOPING,SWEDEN
[2] UMEA UNIV,DEPT GERIATR MED,S-90187 UMEA,SWEDEN
[3] UMEA UNIV,DEPT PSYCHIAT,S-90187 UMEA,SWEDEN
来源：
NEUROBIOLOGY OF AGING | 1991年 / 12卷 / 05期
关键词：
HUMAN PLATELETS; SEROTONIN UPTAKE SITES; ALZHEIMERS DISEASE;
D O I：
10.1016/0197-4580(91)90084-W
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Platelet serotonin (5-hydroxytryptamine, 5-HT) uptake sites were studied in a control group (n = 30) and an Alzheimer group (n = 40) using [H-3]paroxetine as radioligand. The maximum number of binding sites (B(max)) for control (1250 +/- 60 fmol/mg protein) was not different from the Alzheimer group (1280 +/- 40 fmol/mg protein). There were no differences in apparent binding affinity (K(d)): 0.046 (0.024-0.062) nM for control and 0.040 (0.027-0.061) nM for Alzheimer. Thus even though several previous studies have demonstrated marked atrophy of 5-HT containing neurites and 5-HT uptake sites in Alzheimer's disease, these findings are not found in the periphery on platelets. The platelet 5-HT uptake site cannot be used as a peripheral marker of Alzheimer's disease.
引用
收藏
页码：531 / 534
页数：4
相关论文
共 50 条
  • [1] PLATELET 5-HT UPTAKE SITES IN DEPRESSION - 3 CONCURRENT MEASURES USING [H-3] IMIPRAMINE AND [H-3] PAROXETINE
    LAWRENCE, KM
    FALKOWSKI, J
    JACOBSON, RR
    HORTON, RW
    [J]. PSYCHOPHARMACOLOGY, 1993, 110 (1-2) : 235 - 239
  • [2] PLATELET [H-3]-IMIPRAMINE BINDING IS NOT MODIFIED IN ALZHEIMERS-DISEASE
    GALZIN, AM
    DAVOUS, P
    ROUDIER, M
    LAMOUR, Y
    POIRIER, MF
    LANGER, SZ
    [J]. PSYCHIATRY RESEARCH, 1989, 28 (03) : 289 - 294
  • [3] [H-3] TCP BINDING-SITES IN ALZHEIMERS-DISEASE
    MONAGHAN, DT
    GEDDES, JW
    YAO, D
    CHUNG, C
    COTMAN, CW
    [J]. NEUROSCIENCE LETTERS, 1987, 73 (02) : 197 - 200
  • [4] BRAIN 5-HT UPTAKE SITES, LABELED WITH [H-3] PAROXETINE, IN ANTIDEPRESSANT-FREE DEPRESSED SUICIDES
    LAWRENCE, KM
    DEPAERMENTIER, F
    CHEETHAM, SC
    CROMPTON, MR
    KATONA, CLE
    HORTON, RW
    [J]. BRAIN RESEARCH, 1990, 526 (01) : 17 - 22
  • [5] PLATELET 5-HT UPTAKE SITES, LABELED WITH [H-3] PAROXETINE, IN CONTROLS AND DEPRESSED-PATIENTS BEFORE AND AFTER TREATMENT WITH FLUOXETINE OR LOFEPRAMINE
    LAWRENCE, KM
    KATONA, CLE
    ABOUSALEH, MT
    ROBERTSON, MM
    NAIRAC, BL
    EDWARDS, DRL
    LOCK, T
    BURNS, RA
    HARRISON, DA
    HORTON, RW
    [J]. PSYCHOPHARMACOLOGY, 1994, 115 (1-2) : 261 - 264
  • [6] EFFECTS OF FLUOXETINE TREATMENT OF PLATELET H-3 IMIPRAMINE BINDING, 5-HT UPTAKE AND 5-HT CONTENT IN MAJOR DEPRESSIVE DISORDER
    WAGNER, A
    MONTERO, D
    MARTENSSON, B
    SIWERS, B
    ASBERG, M
    [J]. JOURNAL OF AFFECTIVE DISORDERS, 1990, 20 (02) : 101 - 113
  • [7] STEREOSELECTIVE BLOCKADE AT [H-3]5-HT BINDING-SITES AND AT THE 5-HT AUTORECEPTOR BY PROPRANOLOL
    MIDDLEMISS, DN
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1984, 101 (3-4) : 289 - 293
  • [8] [H-3] QUIPAZINE DEGRADATION PRODUCTS LABEL 5-HT UPTAKE SITES
    SCHMIDT, AW
    HURT, SD
    PEROUTKA, SJ
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 171 (01) : 141 - 143
  • [9] CHANGES INDUCED BY CORTICOSTERONE AND ADRENALECTOMY IN SYNAPTOSOMAL AND PLATELET UPTAKE AND BINDING OF 5-HT - THE RELATIONSHIP TO [H-3] IMIPRAMINE BINDING
    LEE, PHK
    CHAN, MY
    [J]. NEUROPHARMACOLOGY, 1985, 24 (11) : 1043 - 1050
  • [10] AGE STABILITY OF HUMAN BRAIN 5-HT TERMINALS STUDIED WITH [H-3] PAROXETINE BINDING
    ANDERSSON, A
    SUNDMAN, I
    MARCUSSON, J
    [J]. GERONTOLOGY, 1992, 38 (03) : 127 - 132
12345