PLATELET [H-3] PAROXETINE BINDING TO 5-HT UPTAKE SITES IN ALZHEIMERS-DISEASE

被引：8
|
作者：
ANDERSSON, A
ADOLFSSON, R
ERIKSSON, K
MARCUSSON, J
机构：
[1] UNIV LINKOPING,DEPT GERIATR MED,S-58246 LINKOPING,SWEDEN
[2] UMEA UNIV,DEPT GERIATR MED,S-90187 UMEA,SWEDEN
[3] UMEA UNIV,DEPT PSYCHIAT,S-90187 UMEA,SWEDEN
来源：
NEUROBIOLOGY OF AGING | 1991年 / 12卷 / 05期
关键词：
HUMAN PLATELETS; SEROTONIN UPTAKE SITES; ALZHEIMERS DISEASE;
D O I：
10.1016/0197-4580(91)90084-W
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Platelet serotonin (5-hydroxytryptamine, 5-HT) uptake sites were studied in a control group (n = 30) and an Alzheimer group (n = 40) using [H-3]paroxetine as radioligand. The maximum number of binding sites (B(max)) for control (1250 +/- 60 fmol/mg protein) was not different from the Alzheimer group (1280 +/- 40 fmol/mg protein). There were no differences in apparent binding affinity (K(d)): 0.046 (0.024-0.062) nM for control and 0.040 (0.027-0.061) nM for Alzheimer. Thus even though several previous studies have demonstrated marked atrophy of 5-HT containing neurites and 5-HT uptake sites in Alzheimer's disease, these findings are not found in the periphery on platelets. The platelet 5-HT uptake site cannot be used as a peripheral marker of Alzheimer's disease.
引用
收藏
页码：531 / 534
页数：4
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