Molecular pathogenesis of malignant gliomas

被引：0
|
作者：
Van de Kelft, E [1 ]
机构：
[1] Onze Lieve Vrouwe Ziekenhuis, Dept Neurosurg, Aalst, Belgium
来源：
11TH EUROPEAN CONGRESS OF NEUROSURGERY: EUROPEAN ASSOCIATION OF NEUROSURGICAL SOCIETIES (EANS) | 1999年
关键词：
D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Current molecular data, combined with age and clinical onset, distinguish at least two subtypes of glioblastomas: de novo and progressive. However, none of the molecular parameters studied so far have shown significant association with patient survival in this disease. The Ip and 19q allelic losses have significant diagnostic and prognostic importance. As targeted therapy begins to be investigated for gene products, genetic analyses will assume an important role in the treatment of patients with malignant gliomas.
引用
收藏
页码：181 / 192
页数：12
相关论文
共 50 条
  • [31] MOLECULAR SIGNATURES UNDERLIE THE DISTINCT FAILURE PATTERNS OF MALIGNANT GLIOMAS
    Choi, Seung Won
    NEURO-ONCOLOGY, 2021, 23 : 10 - 11
  • [32] Malignant gliomas: strategies to increase the effectiveness of targeted molecular treatment
    Wen, Patrick Y.
    Kesari, Santosh
    Drappatz, Jan
    EXPERT REVIEW OF ANTICANCER THERAPY, 2006, 6 (05) : 733 - 754
  • [33] Combining molecular targeted agents with radiation therapy for malignant gliomas
    Scaringi, Claudia
    Enrici, Riccardo Maurizi
    Minniti, Giuseppe
    ONCOTARGETS AND THERAPY, 2013, 6 : 1079 - 1095
  • [34] Molecular pathogenesis and therapeutic implications in pediatric high-grade gliomas
    Juratli, Tareq A.
    Qin, Nan
    Cahill, Daniel P.
    Filbin, Mariella G.
    PHARMACOLOGY & THERAPEUTICS, 2018, 182 : 70 - 79
  • [35] Human malignant mesothelioma: Molecular mechanisms of pathogenesis and progression
    Spugnini, Enrico P.
    Bosari, Silvano
    Citro, Gennaro
    Lorenzon, Italo
    Cognetti, Francesco
    Baldi, Alfonso
    INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2006, 38 (12): : 2000 - 2004
  • [36] Pathogenesis of cerebral pathogenesis of cerebral gliomas, Part II:: Pathogenesis of oligodendrogliomas and gliomas within hereditary disorders
    Kramar, F.
    Zemanova, Z.
    Michalova, K.
    Babicka, L.
    Ransdorfova, S.
    Kozler, P.
    Netuka, D.
    CESKA A SLOVENSKA NEUROLOGIE A NEUROCHIRURGIE, 2006, 69 (06) : 419 - 425
  • [37] Molecular genetic analysis for malignant gliomas: Clinical implication and future directions
    Mizoguchi, Masahiro
    Shono, Tadahisa
    NEUROLOGICAL SURGERY, 2008, 36 (01): : 83 - 91
  • [38] Molecular diagnostic testing in malignant gliomas: A practical update on predictive markers
    Yip, Stephen
    Lafrate, A. John
    Louis, David N.
    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2008, 67 (01): : 1 - 15
  • [39] Radiotherapy in malignant gliomas
    Mohanti, BK
    CANCER JOURNAL - FRANCE, 1997, 10 (01): : 3 - 4
  • [40] Microsurgery for Malignant Gliomas
    M. Gazi Yaşargil
    Paulo A.S. Kadri
    Dianne C.H. Yaşargil
    Journal of Neuro-Oncology, 2004, 69 : 67 - 81
12345