MORPHINE-INDUCED CHANGES IN CEREBRAL AND CEREBELLAR NITRIC-OXIDE SYNTHASE ACTIVITY

被引：26
|
作者：
LEZA, JC
LIZASOAIN, I
SANMARTINCLARK, O
LORENZO, P
机构：
[1] Departmento de Farmacología, Facultad de Medicina, Universidad Complutense de Madrid
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1995年 / 285卷 / 01期
关键词：
MORPHINE; NITRIC OXIDE (NO); NITRIC OXIDE (NO) SYNTHASE; BRAIN;
D O I：
10.1016/0014-2999(95)00474-Y
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effect of acute and chronic morphine treatment on nitric oxide (NO) synthase activity (determined by the rate of conversion of [C-14]arginine into [C-14]citrulline) on mouse brain was studied. Acute morphine treatment induced an increase in Ca2+-dependent NO synthase in cerebellum. This effect was blocked by coadministration with naloxone. Chronic morphine treatment (by s.c. pellet) also produced an increase in cerebellar NO synthase, with a maximum on the second day of implantation. No significant changes were found in frontal cortex and forebrain during acute or chronic morphine treatment. The relationship between opiate effects and the L-arginine:NO pathway is discussed.
引用
收藏
页码：95 / 98
页数：4
相关论文
共 50 条
  • [41] MORPHINE-INDUCED CHANGES IN DISTRIBUTION OF CEREBRAL BLOOD-FLOW
    LAW, W
    KAPIN, M
    LEE, J
    FERGUSON, J
    RITZMANN, R
    FEDERATION PROCEEDINGS, 1983, 42 (03) : 493 - 493
  • [42] GASTRIC-MUCOSAL INJURY IS AMPLIFIED BY INHIBITION OF NITRIC-OXIDE SYNTHASE ACTIVITY AND ATTENUATED BY NITRIC-OXIDE
    RACHMILEWITZ, D
    OKON, E
    KARMELI, F
    GASTROENTEROLOGY, 1995, 108 (04) : A199 - A199
  • [43] NITRIC-OXIDE SYNTHASE IN THE LENS
    IWAKI, M
    FURUKAWA, M
    OGINO, N
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1995, 36 (04) : S262 - S262
  • [44] INHALED NITRIC-OXIDE DOES NOT ALTER ENDOTOXIN-INDUCED NITRIC-OXIDE SYNTHASE ACTIVITY DURING PERFUSION OF THE ISOLATED RAT LUNG
    KURREK, MM
    CASTILLO, L
    BLOCH, KD
    TANNENBAUM, SR
    HURFORD, WE
    ZAPOL, WM
    ANESTHESIOLOGY, 1994, 81 (3A) : A639 - A639
  • [45] NITRIC-OXIDE SYNTHASE IN INVERTEBRATES
    MARTINEZ, A
    HISTOCHEMICAL JOURNAL, 1995, 27 (10): : 770 - 776
  • [46] NITRIC-OXIDE SYNTHASE ASSAYS
    HEVEL, JM
    MARLETTA, MA
    OXYGEN RADICALS IN BIOLOGICAL SYSTEMS, PT C, 1994, 233 : 250 - 258
  • [47] CORRELATION OF ENDOTHELIAL NITRIC-OXIDE SYNTHASE PHOSPHORYLATION WITH SHEAR STRESS-INDUCED NITRIC-OXIDE PRODUCTION
    CORSON, MA
    LATTA, SE
    BERK, BC
    HARRISON, DG
    CIRCULATION, 1994, 90 (04) : 33 - 33
  • [48] INFLUENCE OF NITRIC-OXIDE SYNTHASE INHIBITION, NITRIC-OXIDE AND HYDROPEROXIDE ON INSULIN RELEASE INDUCED BY VARIOUS SECRETAGOGUES
    PANAGIOTIDIS, G
    AKESSON, B
    RYDELL, EL
    LUNDQUIST, I
    BRITISH JOURNAL OF PHARMACOLOGY, 1995, 114 (02) : 289 - 296
  • [49] Nitric oxide synthesis inhibition attenuates morphine-induced place preference
    Kivastik, T
    Rutkauskaite, J
    Zharkovsky, A
    PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1996, 53 (04) : 1013 - 1015
  • [50] SYSTEMIC ADMINISTRATION OF PRAMIRACETAM INCREASES NITRIC-OXIDE SYNTHASE ACTIVITY IN THE CEREBRAL-CORTEX OF THE RAT
    CORASANITI, MT
    PAOLETTI, AM
    PALMA, E
    NAVARRA, M
    NISTICO, G
    FUNCTIONAL NEUROLOGY, 1995, 10 (03) : 151 - 155
12345