MORPHINE-INDUCED CHANGES IN CEREBRAL AND CEREBELLAR NITRIC-OXIDE SYNTHASE ACTIVITY

被引：26
|
作者：
LEZA, JC
LIZASOAIN, I
SANMARTINCLARK, O
LORENZO, P
机构：
[1] Departmento de Farmacología, Facultad de Medicina, Universidad Complutense de Madrid
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1995年 / 285卷 / 01期
关键词：
MORPHINE; NITRIC OXIDE (NO); NITRIC OXIDE (NO) SYNTHASE; BRAIN;
D O I：
10.1016/0014-2999(95)00474-Y
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effect of acute and chronic morphine treatment on nitric oxide (NO) synthase activity (determined by the rate of conversion of [C-14]arginine into [C-14]citrulline) on mouse brain was studied. Acute morphine treatment induced an increase in Ca2+-dependent NO synthase in cerebellum. This effect was blocked by coadministration with naloxone. Chronic morphine treatment (by s.c. pellet) also produced an increase in cerebellar NO synthase, with a maximum on the second day of implantation. No significant changes were found in frontal cortex and forebrain during acute or chronic morphine treatment. The relationship between opiate effects and the L-arginine:NO pathway is discussed.
引用
收藏
页码：95 / 98
页数：4
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