IN-VIVO RELEASE OF INTERLEUKIN-1-BETA INTO HYPOTHALAMIC EXTRACELLULAR FLUID IN RATS - EFFECTS OF REPEATED SAMPLING

被引：8
|
作者：
PHELPS, CP
SAHU, A
OLIVER, J
MA, XL
KALRA, PS
KALRA, SP
MENZIES, RA
CHEN, L
DENKER, M
HORVATH, E
POOLE, LL
机构：
[1] UNIV FLORIDA,COLL MED,DEPT NEUROSCI,GAINESVILLE,FL
[2] UNIV FLORIDA,COLL MED,DEPT PHYSIOL,GAINESVILLE,FL
[3] UNIV S FLORIDA,COLL MED,DEPT PSYCHIAT,TAMPA,FL
来源：
BRAIN RESEARCH | 1995年 / 688卷 / 1-2期
关键词：
INTERLEUKIN-1-BETA; ANTERIOR HYPOTHALAMIC AREA; PARAVENTRICULAR NUCLEUS; PUSH-PULL PERFUSION;
D O I：
10.1016/0006-8993(95)00491-8
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Interleukin-1 beta (Il-1 beta) concentrations in extracellular fluid (ECF) withdrawn at 10-min intervals through a push-pull cannula (PPC) located in the hypothalamus were studied in freely behaving male rats for 1 h at 24 and 72 h and again at 7 days after PPC implantation. Il-1 beta concentrations in ECF were similar in the latter. However, when ECF was sampled at 3 h and again 7 days after PPC implantation, Il-1 beta concentrations were greatly elevated at 7 days when compared to all other intervals. These results demonstrate how the relationships between Il-1 beta measured in ECF and the conditions of measurement appear to be integral parts of a whole intracerebral system: cytokine concentrations appear to be inextricably bound to intrahypothalamic conditions created by the sampling device presence and frequency of use.
引用
收藏
页码：193 / 197
页数：5
相关论文
共 50 条
  • [1] INTERLEUKIN-1-BETA INDUCES HISTAMINE-RELEASE IN THE RAT HYPOTHALAMUS IN-VIVO
    NIIMI, M
    MOCHIZUKI, T
    YAMAMOTO, Y
    YAMATODANI, A
    [J]. NEUROSCIENCE LETTERS, 1994, 181 (1-2) : 87 - 90
  • [2] INTRACOLONIC RELEASE IN-VIVO OF INTERLEUKIN-1-BETA IN CHRONIC ULCERATIVE-COLITIS
    CASELLAS, F
    PAPO, M
    GUARNER, F
    ANTOLIN, M
    SEGURA, RM
    ARMENGOL, JR
    MALAGELADA, JR
    [J]. CLINICAL SCIENCE, 1995, 89 (05) : 521 - 526
  • [3] THE IN-VIVO EFFECT OF INTERLEUKIN-1-BETA ON UREA SYNTHESIS IS MEDIATED BY GLUCOCORTICOIDS IN RATS
    HEINDORFF, H
    ALMDAL, T
    VILSTRUP, H
    [J]. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 1994, 24 (06) : 388 - 392
  • [4] EFFECTS OF RECOMBINANT HUMAN INTERLEUKIN-1-BETA ON HYPOTHALAMIC MONOAMINE METABOLISM OF RATS
    SHIMIZU, H
    UEHARA, Y
    SHIMOMURA, Y
    NEGISHI, M
    TAKAHASHI, S
    KOBAYASHI, I
    KOBAYASHI, S
    [J]. BIOGENIC AMINES, 1990, 7 (05) : 517 - 523
  • [5] IN-VIVO INTRACOLONIC RELEASE OF INTERLEUKIN-1-BETA (IL-1-BETA) IN CHRONIC ULCERATIVE-COLITIS
    CASELLAS, F
    PAPO, M
    GUARNER, F
    ANTOLIN, M
    SEGURA, RM
    ARMENGOL, JR
    MALAGELADA, JR
    [J]. GASTROENTEROLOGY, 1994, 106 (04) : A661 - A661
  • [6] THE EFFECTS OF INTERLEUKIN-1-BETA ON THE HYPOTHALAMIC TACHYKININ, NEUROKININ-A
    KALRA, PS
    DUBE, MG
    KALRA, SP
    [J]. BRAIN RESEARCH, 1994, 662 (1-2) : 178 - 184
  • [7] THERMOREGULATION AND HYPOTHALAMIC HISTAMINE TURNOVER MODULATED BY INTERLEUKIN-1-BETA IN RATS
    KANG, M
    YOSHIMATSU, H
    OGAWA, R
    KUROKAWA, M
    OOHARA, A
    TAMARI, Y
    SAKATA, T
    [J]. BRAIN RESEARCH BULLETIN, 1994, 35 (04) : 299 - 301
  • [8] INHIBITION OF GASTRIC-EMPTYING INDUCED BY INTERLEUKIN-1-BETA INVOLVES HYPOTHALAMIC CRF RELEASE IN RATS
    SUTO, G
    KIRALY, A
    TACHE, Y
    [J]. GASTROENTEROLOGY, 1994, 106 (04) : A574 - A574
  • [9] INTERLEUKIN-1-BETA DIRECTLY EXCITES HYPOTHALAMIC SUPRAOPTIC NEURONS IN RATS INVITRO
    LI, ZH
    INENAGE, K
    KAWANO, S
    KANNAN, H
    YAMASHITA, H
    [J]. NEUROREPORT, 1992, 3 (01) : 91 - 93
  • [10] EFFECTS OF INTERLEUKIN-1-BETA ON MEMBRANE-POTENTIALS OF HYPOTHALAMIC SUPRAOPTIC NEURONS IN RATS IN-VITRO
    YAMASHITA, H
    LI, ZH
    INENAGA, K
    [J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1993, 689 : 689 - 692
12345