IN-VIVO RELEASE OF INTERLEUKIN-1-BETA INTO HYPOTHALAMIC EXTRACELLULAR FLUID IN RATS - EFFECTS OF REPEATED SAMPLING

被引：8
|
作者：
PHELPS, CP
SAHU, A
OLIVER, J
MA, XL
KALRA, PS
KALRA, SP
MENZIES, RA
CHEN, L
DENKER, M
HORVATH, E
POOLE, LL
机构：
[1] UNIV FLORIDA,COLL MED,DEPT NEUROSCI,GAINESVILLE,FL
[2] UNIV FLORIDA,COLL MED,DEPT PHYSIOL,GAINESVILLE,FL
[3] UNIV S FLORIDA,COLL MED,DEPT PSYCHIAT,TAMPA,FL
来源：
BRAIN RESEARCH | 1995年 / 688卷 / 1-2期
关键词：
INTERLEUKIN-1-BETA; ANTERIOR HYPOTHALAMIC AREA; PARAVENTRICULAR NUCLEUS; PUSH-PULL PERFUSION;
D O I：
10.1016/0006-8993(95)00491-8
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Interleukin-1 beta (Il-1 beta) concentrations in extracellular fluid (ECF) withdrawn at 10-min intervals through a push-pull cannula (PPC) located in the hypothalamus were studied in freely behaving male rats for 1 h at 24 and 72 h and again at 7 days after PPC implantation. Il-1 beta concentrations in ECF were similar in the latter. However, when ECF was sampled at 3 h and again 7 days after PPC implantation, Il-1 beta concentrations were greatly elevated at 7 days when compared to all other intervals. These results demonstrate how the relationships between Il-1 beta measured in ECF and the conditions of measurement appear to be integral parts of a whole intracerebral system: cytokine concentrations appear to be inextricably bound to intrahypothalamic conditions created by the sampling device presence and frequency of use.
引用
收藏
页码：193 / 197
页数：5
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