INTERLEUKIN-1-BETA DIRECTLY EXCITES HYPOTHALAMIC SUPRAOPTIC NEURONS IN RATS INVITRO

被引：38

作者：

LI, ZH ^{[1
]}

INENAGE, K ^{[1
]}

KAWANO, S ^{[1
]}

KANNAN, H ^{[1
]}

YAMASHITA, H ^{[1
]}

机构：

[1] UNIV OCCUPAT & ENVIRONM HLTH,SCH MED,DEPT PHYSIOL,YAHATANISHI KU,KITAKYUSHU,FUKUOKA 807,JAPAN

来源：

NEUROREPORT | 1992年 / 3卷 / 01期

关键词：

ARGININE VASOPRESSIN; BRAIN SLICE; INTERLEUKIN-1-BETA; OXYTOCIN; PROSTAGLANDIN; SUPRAOPTIC NUCLEUS;

D O I：

10.1097/00001756-199201000-00024

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

RESPONSES of 42 neurosecretory neurons in the supraoptic nucleus (SON) to human recombinant interleukin-1-beta (IL-1-beta) were examined during intracellular recordings in rat brain slices. IL-1-beta (10(-9)-10(-8)M) depolarized the membrane and caused increased firing in 25 neurons (59.5%). In 11 other neurons (26.6%), depolarization was also seen, followed by membrane hyperpolarization. The IL-induced depolarizing effect remained in the presence of tetrodotoxin (TTX) but was abolished by sodium salicylate. The results suggest that IL-1-beta mainly exerts a direct excitatory effect on SON neurons and further, that prostaglandins may be involved in such an effect.

引用

页码：91 / 93

页数：3

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