INTERLEUKIN-1-BETA ACTS AT HYPOTHALAMIC SITES TO INHIBIT GASTRIC-ACID SECRETION IN RATS

被引：29
|
作者：
SAPERAS, E
YANG, H
TACHE, Y
机构：
[1] VET AFFAIRS WADSWORTH MED CTR, CTR ULCER RES & EDUC, BLDG 115, WILSHIRE & SAWTELLE BLVD, LOS ANGELES, CA 90073 USA
[2] UNIV CALIF LOS ANGELES, DEPT MED, LOS ANGELES, CA 90073 USA
[3] UNIV CALIF LOS ANGELES, BRAIN RES INST, LOS ANGELES, CA 90073 USA
来源：
AMERICAN JOURNAL OF PHYSIOLOGY | 1992年 / 263卷 / 03期
关键词：
PREOPTIC AREA; ANTERIOR HYPOTHALAMUS; PARAVENTRICULAR NUCLEUS; PROSTAGLANDIN-E2; INDOMETHACIN; CENTRAL NERVOUS SYSTEM; GASTRIC SECRETION;
D O I：
10.1152/ajpgi.1992.263.3.G414
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
It has been established that interleukin-1beta (IL-1beta) injected into the cerebrospinal fluid inhibits gastric acid secretion in rats. Brain sites of action of IL-1beta were investigated in conscious rats implanted unilaterally with chronic hypothalamic cannula. Gastric acid secretion was monitored 2 h after pylorus ligation. Human recombinant IL-1beta (10 ng) microinjected into the medial preoptic area, anterior hypothalamus, and paraventricular nucleus inhibited gastric acid secretion by 76-83%. IL-1beta microinjected into the ventromedial hypothalamus and other hypothalamic sites outside of responsive sites had no effect. IL-1beta inhibitory action in the medial preoptic area was dose related (0.1-10 ng), prevented by indomethacin (5 mg/kg ip), and mimicked by prostaglandin E2. These results show that IL-1beta acts in the medial preoptic area/anterior hypothalamus and paraventricular nucleus to inhibit acid secretion in pylorus-ligated rats and that IL-1beta action is likely to involve prostaglandin E2.
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页码：G414 / G418
页数：5
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