PHARMACOKINETICS OF BRAIN NATRIURETIC PEPTIDE IN RATS

被引：0
|
作者：
HASHIMOTO, Y
NAKAO, K
HAMA, N
MUKOYAMA, M
IMURA, H
YASUHARA, M
HORI, R
机构：
[1] KYOTO UNIV HOSP, DEPT PHARM, SAKYO KU, KYOTO 606, JAPAN
[2] KYOTO UNIV, SCH MED, DEPT INTERNAL MED, DIV 2, KYOTO 606, JAPAN
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1992年 / 40卷 / 06期
关键词：
ATRIAL NATRIURETIC PEPTIDE; BRAIN NATRIURETIC PEPTIDE; CLEARANCE; PHARMACOKINETICS;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The pharmacokinetics of rat brain natriuretic peptide (rBNP) was compared with that of alpha-rat atrial natriuretic peptide (alpha-rANP) in rats. After intravenous infusion in rats (600 pmol min-1 kg-1 for 2 min), the disappearance of plasma rBNP was 4-fold slower than that of alpha-rANP. The estimated mean plasma clearance rates for rBNP and alpha-rANP were 45.9 ml min-1 kg-1 and 74.4 ml min-1 kg-1, respectively. The affinity of rBNP for the clearance receptor or degradation enzyme was considered to be lower than that of alpha-rANP.
引用
收藏
页码：1650 / 1652
页数：3
相关论文
共 50 条
  • [41] Brain natriuretic peptide and atrial natriuretic peptide in hypertensive chronic heart failure
    Falcao, LFM
    Pinto, F
    Veiga, F
    Ravara, LP
    van Zwieten, PA
    AMERICAN JOURNAL OF HYPERTENSION, 2004, 17 (05) : 85A - 85A
  • [42] Pulsatile secretion of atrial natriuretic peptide and brain natriuretic peptide in healthy humans
    Pedersen, EB
    Pedersen, HB
    Jensen, KT
    CLINICAL SCIENCE, 1999, 97 (02) : 201 - 206
  • [43] Effects of brain natriuretic peptide on forearm vasculature: comparison with atrial natriuretic peptide
    van der Zander, K
    Houben, AJHM
    Kroon, AA
    de Leeuw, PW
    CARDIOVASCULAR RESEARCH, 1999, 44 (03) : 595 - 600
  • [44] Brain natriuretic peptide: identification of a second natriuretic peptide in human aqueous humour
    Salzmann, J
    Flitcroft, D
    Bunce, C
    Gordon, D
    Wormald, R
    Migdal, C
    BRITISH JOURNAL OF OPHTHALMOLOGY, 1998, 82 (07) : 830 - 834
  • [45] Atrial Natriuretic Peptide and Brain Natriuretic Peptide Release in Human Essential Hypertension
    Soualmia, Hayet
    Ayadi, Ilhem
    Omar, Souheil
    Feki, Moncef
    Drissa, Habiba
    Mebazaa, Abderraouf
    Kaabachi, Naziha
    CLINICAL LABORATORY, 2009, 55 (3-4) : 120 - 127
  • [46] Usefulness of brain natriuretic peptide and N-terminal pro-brain natriuretic peptide in the elderly
    Guillaumou, G.
    Celton, B.
    Ferreira, E.
    Ventura, E.
    Reygrobellet, P.
    Durant, R.
    REVUE DE MEDECINE INTERNE, 2009, 30 (08): : 678 - 685
  • [47] Monoclonal antibody against brain natriuretic peptide and characterization of brain natriuretic peptide-transgenic mice
    Nakagawa, M
    Tanaka, I
    Mukoyama, M
    Suga, S
    Ogawa, Y
    Tamura, N
    Ishibashi, R
    Goto, M
    Nakagawa, O
    Sugawara, A
    Nakao, K
    JOURNAL OF HYPERTENSION, 2001, 19 (03) : 475 - 483
  • [48] PHARMACOKINETICS OF ATRIAL NATRIURETIC PEPTIDE IN YOUNG AND AGED SUBJECTS
    TAN, ACITL
    JANSEN, TLTA
    TERMOND, EFS
    KLOPPENBORG, PWC
    THIEN, T
    BENRAAD, TJ
    PHARMACEUTISCH WEEKBLAD-SCIENTIFIC EDITION, 1988, 10 (06) : 294 - 294
  • [49] PHARMACOKINETICS OF ATRIAL-NATRIURETIC-PEPTIDE IN PEKIN DUCKS
    GRAY, DA
    GENERAL AND COMPARATIVE ENDOCRINOLOGY, 1993, 91 (03) : 267 - 271
  • [50] PHARMACOKINETICS OF VASOPRESSIN AND ATRIAL NATRIURETIC PEPTIDE IN ANESTHETIZED RABBITS
    KING, KA
    COURNEYA, CA
    TANG, C
    WILSON, N
    LEDSOME, JR
    ENDOCRINOLOGY, 1989, 124 (01) : 77 - 83
12345