PHARMACOKINETICS OF BRAIN NATRIURETIC PEPTIDE IN RATS

被引：0
|
作者：
HASHIMOTO, Y
NAKAO, K
HAMA, N
MUKOYAMA, M
IMURA, H
YASUHARA, M
HORI, R
机构：
[1] KYOTO UNIV HOSP, DEPT PHARM, SAKYO KU, KYOTO 606, JAPAN
[2] KYOTO UNIV, SCH MED, DEPT INTERNAL MED, DIV 2, KYOTO 606, JAPAN
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1992年 / 40卷 / 06期
关键词：
ATRIAL NATRIURETIC PEPTIDE; BRAIN NATRIURETIC PEPTIDE; CLEARANCE; PHARMACOKINETICS;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The pharmacokinetics of rat brain natriuretic peptide (rBNP) was compared with that of alpha-rat atrial natriuretic peptide (alpha-rANP) in rats. After intravenous infusion in rats (600 pmol min-1 kg-1 for 2 min), the disappearance of plasma rBNP was 4-fold slower than that of alpha-rANP. The estimated mean plasma clearance rates for rBNP and alpha-rANP were 45.9 ml min-1 kg-1 and 74.4 ml min-1 kg-1, respectively. The affinity of rBNP for the clearance receptor or degradation enzyme was considered to be lower than that of alpha-rANP.
引用
收藏
页码：1650 / 1652
页数：3
相关论文
共 50 条
  • [21] Effects of brain natriuretic peptide on pituitary-adrenal activation in rats
    Jászberényi, M
    Bujdosó, E
    Telegdy, G
    LIFE SCIENCES, 2000, 66 (17) : 1655 - 1661
  • [22] Fluid loading in rats increases serum brain natriuretic peptide concentration
    Inoha, S
    Inamura, T
    Nakamizo, A
    Matushima, T
    Ikezaki, K
    Fukui, M
    NEUROLOGICAL RESEARCH, 2001, 23 (01) : 93 - 95
  • [23] Microalbuminuria versus Brain Natriuretic Peptide in Cardiac Hypertrophy of Hypertensive Rats
    Saliba, Y.
    Chouery, E.
    Megarbane, A.
    Jabbour, H.
    Fares, N.
    PHYSIOLOGICAL RESEARCH, 2010, 59 (06) : 871 - 880
  • [24] Evidence for a novel natriuretic peptide receptor that prefers brain natriuretic peptide over atrial natriuretic peptide
    Goy, MF
    Oliver, PM
    Purdy, KE
    Knowles, JW
    Fox, JE
    Mohler, PJ
    Qian, X
    Smithies, O
    Maeda, N
    BIOCHEMICAL JOURNAL, 2001, 358 (02) : 379 - 387
  • [25] Measuring brain natriuretic peptide
    Prasad, K
    Fredericks, S
    Holt, DW
    LANCET, 1996, 348 (9027): : 626 - 626
  • [26] Brain Type Natriuretic Peptide
    Nash, Patricia L.
    NEONATAL NETWORK, 2008, 27 (05): : 343 - 346
  • [27] NATRIURETIC PEPTIDE RECEPTORS IN THE BRAIN
    LEVIN, ER
    FRANK, HJL
    GELFAND, R
    LOUGHLIN, SE
    CLINICAL RESEARCH, 1990, 38 (01): : A98 - A98
  • [28] Relevance of molecular forms of brain natriuretic peptide for natriuretic peptide research
    Dries, Daniel L.
    HYPERTENSION, 2007, 49 (05) : 971 - 973
  • [29] RECEPTOR SELECTIVITY OF NATRIURETIC PEPTIDE FAMILY, ATRIAL-NATRIURETIC-PEPTIDE, BRAIN NATRIURETIC PEPTIDE, AND C-TYPE NATRIURETIC PEPTIDE
    SUGA, SI
    NAKAO, K
    HOSODA, K
    MUKOYAMA, M
    OGAWA, Y
    SHIRAKAMI, G
    ARAI, H
    SAITO, Y
    KAMBAYASHI, Y
    INOUYE, K
    IMURA, H
    ENDOCRINOLOGY, 1992, 130 (01) : 229 - 239
  • [30] The diagnostic and prognostic value of brain natriuretic peptide and aminoterminal (nt)-pro brain natriuretic peptide
    Weber, T
    Auer, J
    Eber, B
    CURRENT PHARMACEUTICAL DESIGN, 2005, 11 (04) : 511 - 525
12345