PHARMACOKINETICS OF BRAIN NATRIURETIC PEPTIDE IN RATS

被引：0
|
作者：
HASHIMOTO, Y
NAKAO, K
HAMA, N
MUKOYAMA, M
IMURA, H
YASUHARA, M
HORI, R
机构：
[1] KYOTO UNIV HOSP, DEPT PHARM, SAKYO KU, KYOTO 606, JAPAN
[2] KYOTO UNIV, SCH MED, DEPT INTERNAL MED, DIV 2, KYOTO 606, JAPAN
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1992年 / 40卷 / 06期
关键词：
ATRIAL NATRIURETIC PEPTIDE; BRAIN NATRIURETIC PEPTIDE; CLEARANCE; PHARMACOKINETICS;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The pharmacokinetics of rat brain natriuretic peptide (rBNP) was compared with that of alpha-rat atrial natriuretic peptide (alpha-rANP) in rats. After intravenous infusion in rats (600 pmol min-1 kg-1 for 2 min), the disappearance of plasma rBNP was 4-fold slower than that of alpha-rANP. The estimated mean plasma clearance rates for rBNP and alpha-rANP were 45.9 ml min-1 kg-1 and 74.4 ml min-1 kg-1, respectively. The affinity of rBNP for the clearance receptor or degradation enzyme was considered to be lower than that of alpha-rANP.
引用
收藏
页码：1650 / 1652
页数：3
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