COMPOSITION AND ANTIMALARIAL ACTIVITY IN-VITRO OF VOLATILE COMPONENTS OF LIPPIA-MULTIFLORA

被引：63
|
作者：
VALENTIN, A
PELISSIER, Y
BENOIT, F
MARION, C
KONE, D
MALLIE, M
BASTIDE, JM
BESSIERE, JM
机构：
[1] UFR SCI PHARMACEUT, IMMUNOL & PARASITOL LAB, F-34060 MONTPELLIER 1, FRANCE
[2] UFR SCI PHARMACEUT, PHARMACOGNOISE LAB, F-34060 MONTPELLIER 1, FRANCE
[3] UNIV COTE IVOIRE, FAC PHARM, ABIDJAN, COTE IVOIRE
[4] ECOLE NATL SUPER CHIM MONTPELLIER, F-34053 MONTPELLIER 01, FRANCE
来源：
PHYTOCHEMISTRY | 1995年 / 40卷 / 05期
关键词：
LIPPIA MULTIFLORA; VERBENACEAE; VOLATILE COMPONENTS; ANTIMALARIAL; PLASMODIUM FALCIPARUM; IN VITRO;
D O I：
10.1016/0031-9422(95)00522-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The essential oil of Lippia multiflora was prepared by hydrodistillation of leaves and stalks and characterized by GC and mass spectroscopy. The oil was tested for antimalarial activity on in vitro cultures of Plasmodium falciparum (FcB1-Columbia chloroquine-resistant strain and F32-Tanzania chloroquine-sensitive strain). The dilutions inhibiting the in vitro growth of the parasite by 50% 24 and 72 hr after administration of the essential oil to the parasite culture were 1/12 000 and 1/21 000, respectively. When tested on a highly synchronized culture, the essential oil inhibited growth mostly at the trophozoite-schizont step, indicating a potential effect on the first nuclear division of the parasite.
引用
收藏
页码：1439 / 1442
页数：4
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