A DOUBLE-BLIND CROSSOVER PILOT-STUDY OF L-DEPRENYL (SELEGILINE) COMBINED WITH CHOLINESTERASE INHIBITOR IN ALZHEIMERS-DISEASE

被引：0

作者：

SCHNEIDER, LS ^{[1
]}

OLIN, JT ^{[1
]}

PAWLUCZYK, S ^{[1
]}

机构：

[1] UNIV SO CALIF,SCH MED,DEPT PSYCHIAT & BEHAV SCI,LOS ANGELES,CA 90033

来源：

AMERICAN JOURNAL OF PSYCHIATRY | 1993年 / 150卷 / 02期

关键词：

D O I：

暂无

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

The potential efficacy of oral 1-deprenyl (5 mg b.i.d.) added to the regimen of 10 patients with Alzheimer's disease receiving either tacrine or physostigmine was assessed in a double-blind, placebo-controlled, 4-week, two-period crossover pilot study. 1-Deprenyl was associated with significant improvement in scores on the cognitive subscale of the Alzheimer's Disease Assessment Scale, suggesting possible additive effects of 1-deprenyl to the effects of cholinesterase inhibitors.

引用

页码：321 / 323

页数：3

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