A DOUBLE-BLIND CROSSOVER PILOT-STUDY OF L-DEPRENYL (SELEGILINE) COMBINED WITH CHOLINESTERASE INHIBITOR IN ALZHEIMERS-DISEASE

被引：0
|
作者：
SCHNEIDER, LS [1 ]
OLIN, JT [1 ]
PAWLUCZYK, S [1 ]
机构：
[1] UNIV SO CALIF,SCH MED,DEPT PSYCHIAT & BEHAV SCI,LOS ANGELES,CA 90033
来源：
AMERICAN JOURNAL OF PSYCHIATRY | 1993年 / 150卷 / 02期
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D O I：
暂无
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
The potential efficacy of oral 1-deprenyl (5 mg b.i.d.) added to the regimen of 10 patients with Alzheimer's disease receiving either tacrine or physostigmine was assessed in a double-blind, placebo-controlled, 4-week, two-period crossover pilot study. 1-Deprenyl was associated with significant improvement in scores on the cognitive subscale of the Alzheimer's Disease Assessment Scale, suggesting possible additive effects of 1-deprenyl to the effects of cholinesterase inhibitors.
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页码：321 / 323
页数：3
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