SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF CEPHALOSPORINS HAVING C-3 CATECHOL-CONTAINING (PYRIDINIUM-4'-THIO)METHYL GROUPS

被引：5
|
作者：
TSUJI, K [1 ]
YASUMURA, K [1 ]
ISHIKAWA, H [1 ]
机构：
[1] OTSUKA PHARMACEUT CO LTD,FUJII MEM RES INST,OTSU 52001,SHIGA,JAPAN
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 09期
关键词：
D O I：
10.1016/0960-894X(95)00143-H
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Cephalosporins with catechol-containing (pyridinium-4'-thio)methyl groups at C-3 have been synthesized and examined their antibacterial activity. They were found to have high potency against gram-negative bacteria including Pseudomonas aeruginosa. In particular, compound 9c bearing (1'-[N-(3'',4''-dihydroxybenzamide)carbamoylmethyl]pyridinium-4'-thio)methyl group at C-3 exhibited excellent antipseudomonal in vivo efficacy.
引用
收藏
页码：963 / 966
页数：4
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