Synthesis and antibacterial activity of 1β-methyl-2-(5-substituted oxadiazolo pyrrolidin-3-yl-thio)carbapenem derivatives

被引：1
|
作者：
Oh, CH
Dong, HG
Lee, JS
Lee, SC
Hong, JH
Cho, JH [1 ]
机构：
[1] Korea Inst Sci & Technol, Med Chem Res Ctr, Seoul 130650, South Korea
[2] Hawon Pharm Co, Seoul 135080, South Korea
[3] Chosun Univ, Coll Pharm, Kwangju 501759, South Korea
来源：
ARCHIV DER PHARMAZIE | 2003年 / 336卷 / 12期
关键词：
1; beta-methylcarbapenem; antibacterial activity; substituent effect;
D O I：
10.1002/ardp.200300768
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Synthesis of a new series of 1beta-methylcarbapenems with a substituted oxadiazolopyrrolidine moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of the substituent on the oxadiazole ring investigated. In particular, compounds 13 a and 13 c with ester and carbamoyl substituted oxadiazole moieties showed the most potent antibacterial activity
引用
收藏
页码：567 / 572
页数：6
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