DNA methylation profiles in cancer: functions, therapy, and beyond

被引：0
|
作者：
Jinrong Zhu
Yongjie Yang
Li Li
Jiuren Tang
Rongxin Zhang
机构：
[1] School of Life Sciences and Biopharmaceutics
[2] Guangdong Pharmaceutical University
[3] Laboratory of Immunology and Inflammation
来源：
Cancer Biology & Medicine | 2024年 / 21卷 / 02期
关键词：
D O I：
暂无
中图分类号：
R730.2 [肿瘤病理学、病因学];
学科分类号：
100214 ;
摘要：
DNA methylation in cancer DNA methylation, a reversible post-replication modification, defines gene expression and function in different physiologic processes. Hypomethylation is quite common among global DNA modifications, while promoter hypermethylation often occurs in local regions during cancer, as in CpG island formation, thereby perpetuating the inactivation of tumor suppressor genes. Additionally,
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页码：111 / 116
页数：6
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