DNA methylation profiles in cancer: functions, therapy, and beyond

被引：0
|
作者：
Jinrong Zhu
Yongjie Yang
Li Li
Jiuren Tang
Rongxin Zhang
机构：
[1] School of Life Sciences and Biopharmaceutics
[2] Guangdong Pharmaceutical University
[3] Laboratory of Immunology and Inflammation
来源：
Cancer Biology & Medicine | 2024年 / 21卷 / 02期
关键词：
D O I：
暂无
中图分类号：
R730.2 [肿瘤病理学、病因学];
学科分类号：
100214 ;
摘要：
DNA methylation in cancer DNA methylation, a reversible post-replication modification, defines gene expression and function in different physiologic processes. Hypomethylation is quite common among global DNA modifications, while promoter hypermethylation often occurs in local regions during cancer, as in CpG island formation, thereby perpetuating the inactivation of tumor suppressor genes. Additionally,
引用
收藏
页码：111 / 116
页数：6
相关论文
共 50 条
  • [21] DNA methylation profiles of bronchoscopic biopsies for the diagnosis of lung cancer
    Goldmann, Torsten
    Schmitt, Bernhard
    Mueller, Julia
    Kroeer, Maren
    Scheufele, Swetlana
    Marwitz, Sebastian
    Nitschkowski, Dorte
    Schneider, Marc A.
    Meister, Michael
    Muley, Thomas
    Thomas, Michael
    Kugler, Christian
    Rabe, Klaus F.
    Siebert, Reiner
    Reck, Martin
    Ammerpohl, Ole
    CLINICAL EPIGENETICS, 2021, 13 (01)
  • [22] Mitochondrial and nuclear DNA methylation profiles of metastatic cancer cells
    Celik-Uzuner, Selcen
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2017, 40 : S25 - S25
  • [23] Blood DNA methylation profiles improve breast cancer prediction
    Kresovich, Jacob K.
    Xu, Zongli
    O'Brien, Katie M.
    Shi, Min
    Weinberg, Clarice R.
    Sandler, Dale P.
    Taylor, Jack A.
    MOLECULAR ONCOLOGY, 2022, 16 (01) : 42 - 53
  • [24] REDOX REGULATION OF THE EPIGENETIC LANDSCAPE IN CANCER: DNA METHYLATION AND BEYOND
    Domann, Rick
    FREE RADICAL BIOLOGY AND MEDICINE, 2011, 51 : S2 - S2
  • [25] Cancer epigenomics: Implications of DNA methylation in personalized cancer therapy
    Toyota, Minoru
    Suzuki, Hiromu
    Yamashita, Toshiharu
    Hirata, Koichi
    Imai, Kohzoh
    Tokino, Takashi
    Shinomura, Yasuhisa
    CANCER SCIENCE, 2009, 100 (05): : 787 - 791
  • [26] DNA Methylation Array Analysis Identifies Profiles of Blood-Derived DNA Methylation Associated With Bladder Cancer
    Marsit, Carmen J.
    Koestler, Devin C.
    Christensen, Brock C.
    Karagas, Margaret R.
    Houseman, E. Andres
    Kelsey, Karl T.
    JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (09) : 1133 - 1139
  • [27] Beyond the code: the role of histone methylation in cancer resistance and therapy
    Noerenberg, Daniel
    Damm, Frederik
    SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2024, 9 (01)
  • [28] DNA Methylation in Endocrine Therapy Resistant Breast Cancer
    Jawale, Rahul
    Williams, Kristin
    Yang, Howard
    Lee, Maxwell
    Otis, Christopher
    Pentecost, Brian
    Arcaro, Kathleen
    MODERN PATHOLOGY, 2015, 28 : 458A - 459A
  • [29] DNA methylation and cancer therapy: new developments and expectations
    Esteller, M
    CURRENT OPINION IN ONCOLOGY, 2005, 17 (01) : 55 - 60
  • [30] DNA Methylation in Endocrine Therapy Resistant Breast Cancer
    Jawale, Rahul
    Williams, Kristin
    Yang, Howard
    Lee, Maxwell
    Otis, Christopher
    Pentecost, Brian
    Arcaro, Kathleen
    LABORATORY INVESTIGATION, 2015, 95 : 458A - 459A
12345