First cascade Mitsunobu reactions for the synthesis of 2-benzoxazole-N-phenyl and 2-benzimidazole-N-phenyl derivatives

被引：0
|
作者：
Yu Yan
Qifei Zhong
Nan Zhao
Gang Liu
机构：
[1] Institute of Materia Medica,Tsinghua
[2] Chinese Academy of Medical Sciences and Peking Union Medical College,Peking Center for Life Sciences and Department of Pharmacology and Pharmaceutical Sciences, School of Medicine
[3] Tsinghua University,undefined
来源：
Molecular Diversity | 2012年 / 16卷
关键词：
Cascade Mitsunobu reactions; Benzoxazole; Benzimidazole;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
An efficient method has been developed via cascade Mitsunobu reactions to synthesize 2-benzoxazole-N-phenyl and 2-benzimidazole-N-phenyl derivatives, which are common structural motifs in medicinal chemistry. This method also provides a new application of the Mitsunobu reaction.
引用
收藏
页码：157 / 162
页数：5
相关论文
共 50 条
  • [31] Synthesis of N-phenyl-substituted derivatives of morphine alkaloids
    Moiseev, SK
    Bakhanova, IV
    Schmidhammer, H
    Kalinin, VN
    RUSSIAN CHEMICAL BULLETIN, 1999, 48 (03) : 589 - 592
  • [32] Microwave synthesis of various N-phenyl succinimide derivatives
    Guetzloff, Thomas
    Guetzloff, Megan
    Fultz, Micheal
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 255
  • [33] SYNTHESIS AND HERBICIDAL ACTIVITIES OF N-PHENYL OXADIAZOLIDINEDIONE DERIVATIVES
    KIM, HJ
    HWANG, KJ
    PARK, CH
    LEE, JH
    BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 1993, 14 (06) : 717 - 722
  • [34] 2-Phenyl substituted Benzimidazole derivatives: Design, synthesis, and evaluation of their antiproliferative and antimicrobial activities
    Ronak Haj Ersan
    Burak Kuzu
    Derya Yetkin
    Mehmet Abdullah Alagoz
    Aylin Dogen
    Serdar Burmaoglu
    Oztekin Algul
    Medicinal Chemistry Research, 2022, 31 : 1192 - 1208
  • [35] SYNTHESIS AND REACTIONS OF N-PHENYL-BIS(DIETHYLPHOSPHONATO)KETENIMINE
    BESTMANN, HJ
    LEHNEN, H
    TETRAHEDRON LETTERS, 1991, 32 (34) : 4279 - 4282
  • [36] CARCINOGENICITY OF N-PHENYL-1-NAPHTHYLAMINE AND N-PHENYL-2-NAPHTHYLAMINE IN MICE
    WANG, HW
    WANG, D
    DZENG, RW
    CANCER RESEARCH, 1984, 44 (07) : 3098 - 3100
  • [37] SYNTHESIS OF ACYL DERIVATIVES OF 4-PHENYL-2-AZETIDINONE AND THEIR REACTIONS WITH AMINES
    BERGMANN, HJ
    OTTO, HH
    ARCHIV DER PHARMAZIE, 1986, 319 (07) : 635 - 641
  • [38] Synthesis of substituted phenyl N-(2-hydroxybenzyl)-N-methylcarbamates
    Hrabík, O
    Simunek, P
    Mindl, J
    Kaválek, J
    MOLECULES, 2002, 7 (02) : 200 - 205
  • [39] SUBSTITUTION REACTIONS OF PYRIMIDINE AND ITS 2-PHENYL AND 4-PHENYL DERIVATIVES
    LYTHGOE, B
    RAYNER, LS
    JOURNAL OF THE CHEMICAL SOCIETY, 1951, (SEP): : 2323 - 2329
  • [40] Thermochemical properties of two benzimidazole derivatives:: 2-phenyl- and 2-benzylbenzimidazole
    da Silva, MAVR
    da Silva, MDDMCR
    Amaral, LMPF
    Elguero, J
    Jiménez, P
    Roux, MV
    Dávalos, JZ
    Temprado, M
    Cabildo, P
    Claramunt, RM
    Mó, O
    Yáñez, M
    JOURNAL OF CHEMICAL THERMODYNAMICS, 2005, 37 (11): : 1168 - 1176
12345