O-GlcNAcylation: A Crucial Regulator in Cancer-Associated Biological Events

被引：0
|
作者：
Zhihong Ran
Lei Zhang
Ming Dong
Yu Zhang
Lulu Chen
Qibin Song
机构：
[1] Three Gorges University,Medical College
[2] Renmin Hospital of Wuhan University,Cancer Center
[3] Guangzhou National Laboratory,Department of Pediatrics, Tongji Hospital, Tongji Medical College
[4] Huazhong University of Science and Technology,undefined
来源：
Cell Biochemistry and Biophysics | 2023年 / 81卷
关键词：
O-GlcNAc; OGT; Cancer; Biological events;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
O-GlcNAcylation, a recently discovered post-translational modification of proteins, plays a crucial role in regulating protein structure and function, and is closely associated with multiple diseases. Research has shown that O-GlcNAcylation is abnormally upregulated in most cancers, promoting disease progression. To elucidate the roles of O-GlcNAcylation in cancer, this review summarizes various cancer-associated biological events regulated by O-GlcNAcylation and the corresponding signaling pathways. This work may provide insights for future studies on the function or underlying mechanisms of O-GlcNAcylation in cancer.
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页码：383 / 394
页数：11
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