Genetic regulation and manipulation for natural product discovery

被引：0

作者：

Jianwei Chen

Qihao Wu

Usama W. Hawas

Hong Wang

机构：

[1] Zhejiang University of Technology,College of Pharmaceutical Science

[2] King Abdulaziz University,Marine Chemistry Department, Faculty of Marine Science

[3] Zhejiang University of Technology,Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals

来源：

Applied Microbiology and Biotechnology | 2016年 / 100卷

关键词：

Natural product; Regulation and manipulation; Discovery;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Natural products are an important source of modern medical development, e.g., antibiotics, anticancers, immune modulators, etc. and will continue to be a powerful driving force for the discovery of novel potential drugs. In the heterologous hosts, natural products are biosynthesized using dedicated metabolic networks. By gene engineering, pathway reconstructing, and enzyme engineering, metabolic networks can be modified to synthesize novel compounds containing enhanced structural feature or produce a large quantity of known valuable bioactive compounds. The review introduces some important technical platforms and relevant examples of genetic regulation and manipulation to improve natural product titers or drive novel secondary metabolite discoveries.

引用

页码：2953 / 2965

页数：12

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