Efficient synthesis of mono- and disubstituted 2,3-dihydroquinazolin-4(1H)-ones using aluminum methanesulfonate as a reusable catalyst

被引:0
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作者
Zhiguo Song
Lianli Liu
Yang Wang
Xiaohu Sun
机构
[1] Bohai University,Center for Science & Technology Experiment
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关键词
2,3-Dihydroquinazolin-4(1; )-ones; Aluminum methanesulfonate; Multicomponent reactions; Isatoic anhydride;
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摘要
A wide range of mono- and disubstituted 2,3-dihydroquinazolin-4(1H)-ones were synthesized via a one-pot three components condensation of isatoic anhydride, aldehydes, and ammonium salts or primary amines in the presence of aluminum methanesulfonate in EtOH/H2O solution. The catalyst is reusable and could be recycled for several runs without any distinct decrease in its efficiency. A plausible mechanism for this one-pot three components reaction was proposed.
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页码:1091 / 1099
页数:8
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