Mechanisms of Disease: regulation of glucocorticoid and receptor levels—impact on the metabolic syndrome

被引：0
|
作者：
Selma F Witchel
Donald B DeFranco
机构：
[1] Children's Hospital of Pittsburgh,Division of Pediatric Endocrinology
[2] University of Pittsburgh School of Medicine,undefined
来源：
Nature Clinical Practice Endocrinology & Metabolism | 2006年 / 2卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Most tissues express glucocorticoid receptors but tissue-specific modulation of this receptor affects homeostasis, immune responses and cell differentiation mediated by glucocorticoids. This Review describes the mechanisms involved—including nucleocytoplasmic shuttling, degradation and gene polymorphisms—and details the effects on the metabolic syndrome.
引用
收藏
页码：621 / 631
页数：10
相关论文
共 50 条
  • [41] Glucocorticoid regulation of the vitamin D receptor
    Hidalgo, Alejandro A.
    Trump, Donald L.
    Johnson, Candace S.
    JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2010, 121 (1-2): : 372 - 375
  • [42] Selenoprotein P regulation by the glucocorticoid receptor
    Colleen Rock
    Philip J. Moos
    BioMetals, 2009, 22 : 995 - 1009
  • [43] Regulation of triglyceride metabolism by glucocorticoid receptor
    Jen-Chywan Wang
    Nora E Gray
    Taiyi Kuo
    Charles A Harris
    Cell & Bioscience, 2
  • [44] Selenoprotein P regulation by the glucocorticoid receptor
    Rock, Colleen
    Moos, Philip J.
    BIOMETALS, 2009, 22 (06) : 995 - 1009
  • [45] Regulation of triglyceride metabolism by glucocorticoid receptor
    Wang, Jen-Chywan
    Gray, Nora E.
    Kuo, Taiyi
    Harris, Charles A.
    CELL AND BIOSCIENCE, 2012, 2
  • [46] STRUCTURE, FUNCTION AND REGULATION OF THE GLUCOCORTICOID RECEPTOR
    OKRET, S
    DONG, Y
    POELLINGER, L
    DAHLMAN, K
    CARLSTEDTDUKE, J
    GUSTAFSSON, JA
    HIGHLIGHTS OF MODERN BIOCHEMISTRY, VOLS 1-2, 1989, : 389 - 400
  • [47] THE DOWN SIDE OF GLUCOCORTICOID RECEPTOR REGULATION
    BURNSTEIN, KL
    CIDLOWSKI, JA
    MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1992, 83 (01) : C1 - C8
  • [48] Glucocorticoid receptor dynamics and gene regulation
    Biddie, Simon C.
    Hager, Gordon L.
    STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS, 2009, 12 (03): : 193 - 205
  • [49] STRUCTURE AND REGULATION OF THE GLUCOCORTICOID HORMONE RECEPTOR
    ROUSSEAU, GG
    MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1984, 38 (01) : 1 - 11
  • [50] Glucocorticoid receptor regulation of mitochondrial genes
    Antakly, T
    Lafaille, F
    MOLECULAR BIOLOGY OF THE CELL, 2002, 13 : 129A - 129A
12345