Mechanisms of Disease: regulation of glucocorticoid and receptor levels—impact on the metabolic syndrome

被引：0
|
作者：
Selma F Witchel
Donald B DeFranco
机构：
[1] Children's Hospital of Pittsburgh,Division of Pediatric Endocrinology
[2] University of Pittsburgh School of Medicine,undefined
来源：
Nature Clinical Practice Endocrinology & Metabolism | 2006年 / 2卷
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摘要：
Most tissues express glucocorticoid receptors but tissue-specific modulation of this receptor affects homeostasis, immune responses and cell differentiation mediated by glucocorticoids. This Review describes the mechanisms involved—including nucleocytoplasmic shuttling, degradation and gene polymorphisms—and details the effects on the metabolic syndrome.
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页码：621 / 631
页数：10
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