Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis

被引：0
|
作者：
Gracjan Michlewski
Javier F Cáceres
机构：
[1] Medical Research Council Human Genetics Unit,
[2] Institute of Genetics and Molecular Medicine,undefined
[3] Western General Hospital,undefined
来源：
Nature Structural & Molecular Biology | 2010年 / 17卷
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摘要：
let-7a, a miRNA involved in differentiation, was known to be regulated by Lin-28. Now work reveals another factor that could control let-7a levels in vivo: hnRNP A1 binds to unprocessed pri-let-7a and inhibits its processing by Drosha. The inhibitory effect of hnRNP A1 is further shown to occur via antagonizing the binding of KSRP to pri-let-7a, which is known to promote biogenesis.
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页码：1011 / 1018
页数：7
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