Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis

被引：0
|
作者：
Gracjan Michlewski
Javier F Cáceres
机构：
[1] Medical Research Council Human Genetics Unit,
[2] Institute of Genetics and Molecular Medicine,undefined
[3] Western General Hospital,undefined
来源：
Nature Structural & Molecular Biology | 2010年 / 17卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
let-7a, a miRNA involved in differentiation, was known to be regulated by Lin-28. Now work reveals another factor that could control let-7a levels in vivo: hnRNP A1 binds to unprocessed pri-let-7a and inhibits its processing by Drosha. The inhibitory effect of hnRNP A1 is further shown to occur via antagonizing the binding of KSRP to pri-let-7a, which is known to promote biogenesis.
引用
收藏
页码：1011 / 1018
页数：7
相关论文
共 50 条
  • [31] Critical role of hnRNP A1 in HTLV-1 replication in human transformed T lymphocytes
    Elsa Kress
    Hicham Hachem Baydoun
    Françoise Bex
    Louis Gazzolo
    Madeleine Duc Dodon
    Retrovirology, 2
  • [32] Let-7a inhibits growth and migration of breast cancer cells by targeting HMGA1
    Liu, Kui
    Zhang, Chunfu
    Li, Tao
    Ding, Yanling
    Tu, Tao
    Zhou, Fangfang
    Qi, Wenkai
    Chen, Huabiao
    Sun, Xiaochun
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2015, 46 (06) : 2526 - 2534
  • [33] Downregulation of MST4 Underlies a Novel Inhibitory Role of MicroRNA Let-7a in the Progression of Retinoblastoma
    Zhang, Xinli
    Song, Lili
    Huang, Yanxia
    Han, Shaoping
    Hou, Min
    Li, Hongxia
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2020, 61 (06)
  • [34] Roles for SR proteins and hnRNP A1 in the regulation of c-src exon N1
    Rooke, N
    Markovtsov, V
    Cagavi, E
    Black, DL
    MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (06) : 1874 - 1884
  • [35] MicroRNA let-7a and let-7f as novel regulatory factors of the sika deer (Cervus nippon) IGF-1R gene
    Hu, Wei
    Li, Ting
    Hu, Rui
    Wu, Lei
    Li, Mu
    Meng, Xingyu
    GROWTH FACTORS, 2014, 32 (01) : 27 - 33
  • [36] Pri-let-7a-1 rs10739971 polymorphism is associated with gastric cancer prognosis and might affect mature let-7a expression
    Li, Ying
    Xu, Qian
    Liu, Jingwei
    He, Caiyun
    Yuan, Quan
    Xing, Chengzhong
    Yuan, Yuan
    ONCOTARGETS AND THERAPY, 2016, 9 : 3951 - +
  • [37] A role for the M9 transport signal of hnRNP A1 in mRNA nuclear export
    Izaurralde, E
    Jarmolowski, A
    Beisel, C
    Mattaj, IW
    Dreyfuss, G
    Fischer, U
    JOURNAL OF CELL BIOLOGY, 1997, 137 (01): : 27 - 35
  • [38] A comprehensive understanding of hnRNP A1 role in cancer: new perspectives on binding with noncoding RNA
    Luisa Siculella
    Laura Giannotti
    Benedetta Di Chiara Stanca
    Francesco Spedicato
    Matteo Calcagnile
    Stefano Quarta
    Marika Massaro
    Fabrizio Damiano
    Cancer Gene Therapy, 2023, 30 : 394 - 403
  • [39] A comprehensive understanding of hnRNP A1 role in cancer: new perspectives on binding with noncoding RNA
    Siculella, Luisa
    Giannotti, Laura
    Stanca, Benedetta Di Chiara
    Spedicato, Francesco
    Calcagnile, Matteo
    Quarta, Stefano
    Massaro, Marika
    Damiano, Fabrizio
    CANCER GENE THERAPY, 2023, 30 (03) : 394 - 403
  • [40] Up-regulation of hnRNP A1, Ezrin, tubulin β-2C and Annexin A1 in sentinel lymph nodes of colorectal cancer
    Zhen-Yu He
    World Journal of Gastroenterology, 2010, 16 (37) : 4670 - 4676
12345