Synthesis and antitumor activity of 3,4,5-substituted 1,2,4-triazoles

被引：0
|
作者：
T. R. Ovsepyan
R. G. Melik-Ogandzhanyan
G. A. Panosyan
F. G. Arsenyan
B. T. Garibdzhanyan
机构：
[1] National Academy of Sciences of Armenia,Mndzhoyan Institute of Fine Organic Chemistry, Molecular Structure Research Center
来源：
Pharmaceutical Chemistry Journal | 2009年 / 43卷
关键词：
synthesis; 1,2,4-triazole; antitumor activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Conditions for effective alkylation of new 3,4-substituted-5-mercapto-1,2,4-triazoles with various alkylating agents are established. Several compounds possessing pronounced antitumor activity have been found in experiments using two xenograft tumor models.
引用
收藏
页码：645 / 648
页数：3
相关论文
共 50 条
  • [31] Synthesis of substituted 1,2,4-triazoles and 1,3,4-thiadiazoles
    Hovsepian T.R.
    Dilanian E.R.
    Engoyan A.P.
    Melik-Ohanjanian R.G.
    Chemistry of Heterocyclic Compounds, 2004, 40 (09) : 1194 - 1198
  • [32] Synthesis and antitumor activity of 5-methylbenzofuryl-substituted 1,2,4-triazoles and triazoline-5-thiones
    M. A. Kaldrikyan
    R. G. Melik-Oganjanyan
    F. H. Aresnyan
    Pharmaceutical Chemistry Journal, 2013, 47 : 191 - 194
  • [33] Synthesis of substituted 1,2,4-triazoles and 1,3,4-thiadiazoles
    Hovsepian, TR
    Dilanian, ER
    Engoian, AP
    Melik-Ohanjanian, RG
    KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 2004, (09): : 1377 - 1381
  • [34] APPROACHES TO THE SYNTHESIS OF 1-SUBSTITUTED 1,2,4-TRIAZOLES
    BALASUBRAMANIAN, M
    KEAY, JG
    SCRIVEN, EFV
    HETEROCYCLES, 1994, 37 (03) : 1951 - 1975
  • [35] SYNTHESIS AND ANTITUMOR ACTIVITY OF A SERIES OF BENZOFURYL-SUBSTITUTED 1,2,4-TRIAZOLES AND TRIAZOLIN-5-THIONES
    Kaldrikyan, M. A.
    Grigoryan, L. A.
    Melik-Ogandzhanyan, R. G.
    Arsenyan, F. G.
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2011, 45 (04) : 211 - 214
  • [36] Synthesis and antitumor activity of 5-methylbenzofuryl-substituted 1,2,4-triazoles and triazoline-5-thiones
    Kaldrikyan, M. A.
    Melik-Oganjanyan, R. G.
    Aresnyan, F. H.
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2013, 47 (04) : 191 - 194
  • [37] Synthesis and antitumor activity of a series of benzofuryl-substituted 1,2,4-triazoles and triazolin-5-thiones
    Kaldrikyan M.A.
    Grigoryan L.A.
    Melik-Ogandzhanyan R.G.
    Arsenyan F.G.
    Pharmaceutical Chemistry Journal, 2011, 45 (4) : 211 - 214
  • [38] SYNTHESIS OF UNSYMMETRICALLY SUBSTITUTED 4H-1,2,4-TRIAZOLES
    CARLSEN, HJ
    JORGENSEN, KB
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1994, 31 (04) : 805 - 807
  • [39] 1,2,4-TRIAZOLES .4. TAUTOMERISM OF 3,5-DISUBSTITUTED 1,2,4-TRIAZOLES
    KUBOTA, S
    UDA, M
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1975, 23 (05) : 955 - 966
  • [40] SYNTHESIS AND BLEACHING ACTIVITY OF 3-PROPARGYLTHIO-4-(SUBSTITUTED PHENYL)-4H-1,2,4-TRIAZOLES
    TAKEHARA, K
    YAMADA, N
    HAKIRA, H
    KUWANO, E
    TANIGUCHI, E
    JOURNAL OF PESTICIDE SCIENCE, 1995, 20 (03) : 291 - 297
12345