Synthesis, Physicochemical and Pharmacological Properties of N,N',N'', N'''-Substituted Amides of 1,1,3,3-Propanetetracarboxylic Acid

被引：0

作者：

P. A. Bezuglyi

V. A. Georgiyants

L. A. Perekhoda

N. V. Garnaya

I. A. Sych

机构：

[1] Ukrainian Pharmaceutical Academy,

来源：

Russian Journal of Organic Chemistry | 2003年 / 39卷

关键词：

Toxicity; Organic Chemistry; Amide; Dichloromethane; Good Yield;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

By condensation of symmetrical malonic acid diamides with dichloromethane (method a) and with paraform (method b) N,N',N'',N'''-substituted amides of 1,1,3,3-propanetetracarboxylic acid were synthesized. Better yields of the target products (68-80%) and the use of less toxic reagents indicate that method b is more feasible. The primary pharmacological screening revealed that the compounds obtained possess pronounced anticonvulsant activity at moderate toxicity.

引用

页码：475 / 477

页数：2

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