Synthesis, Physicochemical and Pharmacological Properties of N,N',N'', N'''-Substituted Amides of 1,1,3,3-Propanetetracarboxylic Acid

被引：0
|
作者：
P. A. Bezuglyi
V. A. Georgiyants
L. A. Perekhoda
N. V. Garnaya
I. A. Sych
机构：
[1] Ukrainian Pharmaceutical Academy,
来源：
Russian Journal of Organic Chemistry | 2003年 / 39卷
关键词：
Toxicity; Organic Chemistry; Amide; Dichloromethane; Good Yield;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
By condensation of symmetrical malonic acid diamides with dichloromethane (method a) and with paraform (method b) N,N',N'',N'''-substituted amides of 1,1,3,3-propanetetracarboxylic acid were synthesized. Better yields of the target products (68-80%) and the use of less toxic reagents indicate that method b is more feasible. The primary pharmacological screening revealed that the compounds obtained possess pronounced anticonvulsant activity at moderate toxicity.
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页码：475 / 477
页数：2
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