New inhibitors of 5-lipoxygenase catalytic activity based on 2-(3-methylphenyl)propanoic acid and 4-substituted morpholine derivatives

被引：0
|
作者：
V. R. Khayrullina
I. A. Taipov
A. V. Veselovsky
D. S. Shcherbinin
A. Ya. Gerchikov
机构：
[1] Bashkir State University,Faculty of Chemistry
[2] Russian Academy of Medical Sciences,Orekhovich Institute of Biomedical Chemistry
来源：
Biochemistry (Moscow) | 2014年 / 79卷
关键词：
molecular design; molecular docking; 5-lipoxygenase; cyclooxygenase isoforms;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
New potential inhibitors of 5-lipoxygenase (5-LOX) based on the structure of 2-(3-benzoylphenyl)propanoic acid (an active component of the nonsteroidal antiinflammatory drug Ketoprofen) were designed using the SARD-21 program. The docking of these compounds in the active site of 5-LOX suggested that seven compounds can interact with this enzyme. Two of them can also be dual inhibitors of 5-LOX and two isoforms of cyclooxygenase.
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页码：376 / 384
页数：8
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