New inhibitors of 5-lipoxygenase catalytic activity based on 2-(3-methylphenyl)propanoic acid and 4-substituted morpholine derivatives

被引：0

作者：

V. R. Khayrullina

I. A. Taipov

A. V. Veselovsky

D. S. Shcherbinin

A. Ya. Gerchikov

机构：

[1] Bashkir State University,Faculty of Chemistry

[2] Russian Academy of Medical Sciences,Orekhovich Institute of Biomedical Chemistry

来源：

Biochemistry (Moscow) | 2014年 / 79卷

关键词：

molecular design; molecular docking; 5-lipoxygenase; cyclooxygenase isoforms;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

New potential inhibitors of 5-lipoxygenase (5-LOX) based on the structure of 2-(3-benzoylphenyl)propanoic acid (an active component of the nonsteroidal antiinflammatory drug Ketoprofen) were designed using the SARD-21 program. The docking of these compounds in the active site of 5-LOX suggested that seven compounds can interact with this enzyme. Two of them can also be dual inhibitors of 5-LOX and two isoforms of cyclooxygenase.

引用

页码：376 / 384

页数：8

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