Calcium cycling proteins in heart failure, cardiomyopathy and arrhythmias

被引：0
|
作者：
Susumu Minamisawa
Yoji Sato
Myeong-Chan Cho
机构：
[1] Yokohama City University School of Medicine,Department of Physiology
来源：
Experimental & Molecular Medicine | 2004年 / 36卷
关键词：
calcium ATPase; calcium homeostasis; cardiomyopathy; heart failure; phospholamban; ryanodine receptor; sarcoplasmic reticulum;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A growing body of evidence, including studies using genetically engineered mouse models, has shown that Ca2+ cycling and Ca2+ -dependent signaling pathways play a pivotal role in cardiac hypertrophy and heart failure. In addition, recent studies identified that mutations of the genes encoding sarcoplasmic reticulum (SR) proteins cause human cardiomyopathies and lethal ventricular arrhythmias. The regulation of Ca2+ homeostasis via the SR proteins may have potential therapeutic value for heart diseases such as cardiomyopathy, heart failure and arrhythmias.
引用
收藏
页码：193 / 203
页数：10
相关论文
共 50 条
  • [41] PKD2 mutations lead to impaired calcium cycling in the heart and predispose to heart failure
    Paavola, Jere
    Schliffke, Simon
    Rossetti, Sandro
    Kuo, Ivana
    Yuan, Shiaulou
    Sun, Zhaoxia
    Harris, Peter
    Torres, Vicente
    Ehrlich, Barbara
    CIRCULATION, 2012, 125 (19) : E681 - E681
  • [42] MYOCARDIAL CALCIUM CYCLING DEFECT IN FURAZOLIDONE CARDIOMYOPATHY
    OBRIEN, PJ
    SHEN, H
    WEILER, JE
    MIRSALIMI, SM
    JULIAN, RJ
    CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1991, 69 (12) : 1833 - 1840
  • [43] Altered sarcoplasmic reticulum calcium cycling-targets for heart failure therapy
    Kho, Changwon
    Lee, Ahyoung
    Hajjar, Roger J.
    NATURE REVIEWS CARDIOLOGY, 2012, 9 (12) : 717 - 733
  • [44] Reversal of calcium cycling defects in advanced heart failure -: Toward molecular therapy
    Hoshijima, Masahiko
    Knoll, Ralph
    Pashmforoush, Mohammad
    Chien, Kenneth R.
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2006, 48 (09) : A15 - A23
  • [45] Effect of spironolactone on ventricular arrhythmias in congestive heart failure secondary to idiopathic dilated or to ischemic cardiomyopathy
    Ramires, FJA
    Mansur, A
    Coelho, O
    Moranhao, M
    Gruppi, CJ
    Mady, C
    Ramires, JAF
    AMERICAN JOURNAL OF CARDIOLOGY, 2000, 85 (10): : 1207 - 1211
  • [46] Heart failure does not alter propofol effects on sarcoplasmic reticular calcium cycling
    Heerdt, PM
    The, A
    Lee, DL
    ANESTHESIOLOGY, 2000, 93 (3A) : U138 - U138
  • [47] Polycystin-2 mutations lead to impaired calcium cycling in the heart and predispose to dilated cardiomyopathy
    Paavola, Jere
    Schliffke, Simon
    Rossetti, Sandro
    Kuo, Ivana Y. -T.
    Yuan, Shiaulou
    Sun, Zhaoxia
    Harris, Peter C.
    Torres, Vicente E.
    Ehrlich, Barbara E.
    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2013, 58 : 199 - 208
  • [48] Management of Arrhythmias in Severe Heart Failure
    Shiga, Tsuyoshi
    JOURNAL OF CARDIAC FAILURE, 2014, 20 (10) : S138 - S138
  • [49] Digoxin in heart failure and cardiac arrhythmias
    Campbell, TJ
    MacDonald, PS
    MEDICAL JOURNAL OF AUSTRALIA, 2003, 179 (02) : 98 - 102
  • [50] VENTRICULAR ARRHYTHMIAS IN HEART-FAILURE
    GORGELS, APM
    VOS, MA
    SMEETS, JLRM
    WELLENS, HJJ
    AMERICAN JOURNAL OF CARDIOLOGY, 1992, 70 (10): : C37 - C43
12345