Calcium cycling proteins in heart failure, cardiomyopathy and arrhythmias

被引：0
|
作者：
Susumu Minamisawa
Yoji Sato
Myeong-Chan Cho
机构：
[1] Yokohama City University School of Medicine,Department of Physiology
来源：
Experimental & Molecular Medicine | 2004年 / 36卷
关键词：
calcium ATPase; calcium homeostasis; cardiomyopathy; heart failure; phospholamban; ryanodine receptor; sarcoplasmic reticulum;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A growing body of evidence, including studies using genetically engineered mouse models, has shown that Ca2+ cycling and Ca2+ -dependent signaling pathways play a pivotal role in cardiac hypertrophy and heart failure. In addition, recent studies identified that mutations of the genes encoding sarcoplasmic reticulum (SR) proteins cause human cardiomyopathies and lethal ventricular arrhythmias. The regulation of Ca2+ homeostasis via the SR proteins may have potential therapeutic value for heart diseases such as cardiomyopathy, heart failure and arrhythmias.
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页码：193 / 203
页数：10
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