Synthesis of sodium 5-sulfate-ivermectin and disodium 4″,5-disulfate-ivermectin

被引：0
|
作者：
M. A. Shchetinina
E. I. Chernoburova
N. G. Kolotyrkina
M. Kh. Dzhafarov
F. I. Vasilevich
I. V. Zavarzin
机构：
[1] Russian Academy of Sciences,N. D. Zelinsky Institute of Organic Chemistry
[2] K. I. Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology,undefined
来源：
Russian Chemical Bulletin | 2018年 / 67卷
关键词：
sulfation; ivermectin; sulfuric acid; acetic anhydride; sodium salt of ivermectin 5-sulfate; disodium salt of ivermectin 4″,5-disulfate;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Treatment of ivermectin with sulfuric acid–acetic anhydride in pyridine gives sodium 5-sulfate-ivermectin and disodium 4″,5-disulfate-ivermectin. The synthesized salts are water-soluble compounds with promising antiparasitic activity.
引用
收藏
页码：836 / 839
页数：3
相关论文
共 50 条
  • [31] Anilinium 5-sulfosalicylate electropolymerization on mild steel from an aqueous solution of sodium 5-sulfosalicylate/disodium 5-sulfosalicylate
    Ciric-Marjanovic, G. N.
    Marjanovic, B. N.
    Popovic, M. M.
    Panic, V. V.
    Miskovic-Stankovic, V. B.
    RUSSIAN JOURNAL OF ELECTROCHEMISTRY, 2006, 42 (12) : 1358 - 1364
  • [32] Nuclear localization of dengue virus (DENV) 1-4 non-structural protein 5; protection against all 4 DENV serotypes by the inhibitor Ivermectin
    Tay, M. Y. F.
    Fraser, J. E.
    Chan, W. K. K.
    Moreland, N. J.
    Rathore, A. P.
    Wang, C.
    Vasudevan, S. G.
    Jans, D. A.
    ANTIVIRAL RESEARCH, 2013, 99 (03) : 301 - 306
  • [33] Chemical Synthesis of Δ-4,5 Unsaturated Heparan Sulfate Oligosaccharides for Biomarker Discovery
    Joshi, Apoorva
    Chopra, Pradeep
    Venot, Andre
    Boons, Geert-Jan
    ORGANIC LETTERS, 2024, 26 (12) : 2462 - 2466
  • [34] Benzyl Benzoate 25% Versus Permethrin 5% for Scabies. Are Topical Drugs Still Required in the Oral Ivermectin Era?
    Tancredi, Vittorio
    Licata, Gaetano
    Damiani, Luca
    Benvenuto, Pierfrancesco
    Argenziano, Giuseppe
    Giorgio, Caterina Mariarosaria
    DERMATOLOGY PRACTICAL & CONCEPTUAL, 2025, 15 (01):
  • [35] Impact of Ae-GRD on Ivermectin Resistance and Its Regulation by miR-71-5p in Aedes aegypti
    Yu, Lingling
    Yin, Yanan
    Wang, Qiuhui
    Zhao, Peizhen
    Han, Qian
    Liao, Chenghong
    INSECTS, 2024, 15 (06)
  • [36] The effect of 5 years of annual treatment with ivermectin (Mectizan®) on the prevalence and morbidity of onchocerciasis in the village of Gami in the Central African Republic
    Kennedy, MH
    Bertocchi, I
    Hopkins, AD
    Meredith, SE
    ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, 2002, 96 (03): : 297 - 307
  • [37] SYNTHESIS OF ANALOGS OF 5(4)-AMINOIMIDAZOLE-4(5)-CARBOXAMIDE AND PURINES .4. SYNTHESIS OF DERIVATIVES OF 5(4)-MERCAPTOIMIDAZOLE-4(5)-CARBOXYLIC ACID
    OFITSEROV, VI
    MOKRUSHIN, VS
    NIFONTOV, VI
    PUSHKAREVA, ZV
    NIKIFOROVA, NV
    LYCH, LN
    KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1975, (11): : 1550 - 1554
  • [38] Disodium 4,5,6-trihydroxybenzene-1,3-disulfonate dihydrate
    Song, E.
    Podschun, J.
    Wilberts, H.
    Beginn, U.
    Reuter, H.
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2010, 66 : M1265 - U907
  • [39] SYNTHESIS OF 5(4)-AMINO-4(5)-IMIDAZOLCARBOXAMIDE ANALOGS
    MOKRUSHIN, VS
    NIFONTOV, VI
    PUSHKARE.ZV
    OFITSERO.VI
    KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1971, (10): : 1421 - +
  • [40] A COMMUNITY TRIAL OF IVERMECTIN FOR ONCHOCERCIASIS IN SIERRA-LEONE - ADVERSE REACTIONS AFTER THE 1ST 5 TREATMENT ROUNDS
    WHITWORTH, JAG
    MORGAN, D
    MAUDE, GH
    DOWNHAM, MD
    TAYLOR, DW
    TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1991, 85 (04) : 501 - 505
12345