Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis

被引：0
|
作者：
Jennifer C King
Jin Xu
John Wongvipat
Haley Hieronymus
Brett S Carver
David H Leung
Barry S Taylor
Chris Sander
Robert D Cardiff
Suzana S Couto
William L Gerald
Charles L Sawyers
机构：
[1] Human Oncology and Pathogenesis Program,Department of Physiology and Biophysics
[2] Memorial Sloan-Kettering Cancer Center,Department of Pathology and Laboratory Medicine
[3] Computational and Systems Biology Center,undefined
[4] Memorial Sloan-Kettering Cancer Center,undefined
[5] Weill Medical College of Cornell University,undefined
[6] Center for Comparative Medicine,undefined
[7] University of California,undefined
[8] Laboratory of Comparative Pathology,undefined
[9] Memorial Sloan-Kettering Cancer Center,undefined
[10] Howard Hughes Medical Institute,undefined
[11] Memorial Sloan-Kettering Cancer Center,undefined
来源：
Nature Genetics | 2009年 / 41卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Charles Sawyers and colleagues report that mice expressing a TMPRSS2-ERG fusion develop prostatic intraepithelial neoplasia, but only in the context of PI3-kinase pathway activation mediated by either Pten loss or Akt activation. They also find that human TMPRSS2-ERG–positive tumors are enriched for PTEN loss, suggesting that these two events cooperate in human prostate tumorigenesis.
引用
收藏
页码：524 / 526
页数：2
相关论文
共 50 条
  • [21] Immunohistochemical Evaluation of TMPRSS2-ERG Gene Fusion in Adenosis of the Prostate
    Green, W. M.
    Hicks, J. L.
    DeMarzo, A.
    Epstein, J. I.
    MODERN PATHOLOGY, 2012, 25 : 209A - 210A
  • [22] TMPRSS2-ERG gene fusion in transition zone prostate cancer
    Bismar, Tarek A.
    Trpkov, Kiril
    MODERN PATHOLOGY, 2010, 23 (07) : 1040 - 1041
  • [23] Prognostic Significance of TMPRSS2-ERG Fusion in Prostate Cancer Progression
    Toubaji, A.
    Meeker, A.
    Albadine, R.
    Fedor, H.
    De Marzo, A. M.
    Netto, G. J.
    JOURNAL OF MOLECULAR DIAGNOSTICS, 2008, 10 (06): : 609 - 609
  • [24] TMPRSS2-ERG Gene Fusion in Small Cell Carcinoma of the Prostate
    Dancer, J. Y.
    Zuo, G.
    Soto, C.
    Troncoso, P.
    Czerniak, B. A.
    Guo, C. C.
    LABORATORY INVESTIGATION, 2009, 89 : 164A - 165A
  • [25] Detection of TMPRSS2-ERG fusion genes in prostate benign hyperplasia
    Dimitriadis, E.
    Kontogianni-Katsarou, K.
    Velaeti, S.
    Savvani, A.
    Kanelis, G.
    Apostolaki, A.
    Pandis, N.
    Petraki, K.
    HISTOPATHOLOGY, 2008, 53 : 326 - 326
  • [26] TMPRSS2-ERG gene fusion in small cell carcinoma of the prostate
    Guo, Charles C.
    Dancer, Jane Y.
    Wang, Yan
    Aparicio, Ana
    Navone, Nora M.
    Troncoso, Patricia
    Czerniak, Bogdan A.
    HUMAN PATHOLOGY, 2011, 42 (01) : 11 - 17
  • [27] Detection of TMPRSS2-ERG fusion gene in benign prostate hyperplasia
    Velaeti, S.
    Kalogeropoulos, T.
    Karaolidis, T.
    Dimitriadis, E.
    Kontogianni-Katsarou, K.
    Savvani, A.
    Mpisias, S.
    Stefanakis, S.
    Pandis, N.
    Petraki, K.
    EUROPEAN UROLOGY SUPPLEMENTS, 2009, 8 (08) : 614 - 614
  • [28] PCA3 AND TMPRSS2-ERG: MOLECULAR URINE TESTS IN PROSTATE CANCER
    Rittenhouse, H.
    TUMOR BIOLOGY, 2010, 31 : S27 - S28
  • [29] TMPRSS2-ERG Gene Fusion in Small Cell Carcinoma of the Prostate
    Dancer, J. Y.
    Zuo, G.
    Soto, C.
    Troncoso, P.
    Czerniak, B. A.
    Guo, C. C.
    MODERN PATHOLOGY, 2009, 22 : 164A - 165A
  • [30] Incidence and prognostic impact of TMPRSS2-ERG fusion in prostate cancer
    Schoppe, M.
    Perner, S.
    Stenzel, E.
    Muller, M.
    Willers, R.
    Gabbert, H. E.
    Rubin, M. A.
    Engers, R.
    ONKOLOGIE, 2008, 31 : 182 - 182
12345